Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

被引：2
作者：
Wang, Kang [1 ]
Yang, Zihui [1 ]
Zhang, Boyu [1 ]
Gong, Song [2 ]
Wu, Yiping [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast & Cosmet Surg, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Div Endocrinol, Wuhan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷
关键词：
diabetes; wound healing; ADSC-exos; tissue regeneration; skin cells; inflammation; EXTRACELLULAR VESICLES; TRANSFERRIN RECEPTOR; INFLAMMATION; MACROPHAGES; HYDROGEL; THERAPY; POLARIZATION; DYSFUNCTION; BIOGENESIS; ACTIVATION;
D O I：
10.2147/IJN.S466034
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Wound healing in diabetic patients is frequently hampered. Adipose-derived stem cell exosomes (ADSC-eoxs), serving as a crucial mode of intercellular communication, exhibit promising therapeutic roles in facilitating wound healing. This review aims to comprehensively outline the molecular mechanisms through which ADSC-eoxs enhance diabetic wound healing. We emphasize the biologically active molecules released by these exosomes and their involvement in signaling pathways associated with inflammation modulation, cellular proliferation, vascular neogenesis, and other pertinent processes. Additionally, the clinical application prospects of the reported ADSC-eoxs are also deliberated. A thorough understanding of these molecular mechanisms and potential applications is anticipated to furnish a theoretical groundwork for combating diabetic wound healing.
引用
收藏
页码：6015 / 6033
页数：19
相关论文
共 151 条
  • [1] Adipose-Derived Stem Cell: "Treat or Trick"
    Airuddin, Siti Syahira
    Halim, Ahmad Sukari
    Sulaiman, Wan Azman Wan
    Kadir, Ramlah
    Nasir, Nur Azida Mohd
    [J]. BIOMEDICINES, 2021, 9 (11)
  • [2] Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds
    Aitcheson, Savannah M.
    Frentiu, Francesca D.
    Hurn, Sheree E.
    Edwards, Katie
    Murray, Rachael Z.
    [J]. MOLECULES, 2021, 26 (16):
  • [3] Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions
    Al Sadoun, Hadeel
    [J]. CELLS, 2022, 11 (15)
  • [4] Exosomes from adipose-derived stem cells and application to skin wound healing
    An, Yang
    Lin, Shuyan
    Tan, Xiaojie
    Zhu, Shiou
    Nie, Fangfei
    Zhen, Yonghuan
    Gu, Luosha
    Zhang, Chunlei
    Wang, Baicheng
    Wei, Wei
    Li, Dong
    Wu, Junhao
    [J]. CELL PROLIFERATION, 2021, 54 (03)
  • [5] Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review
    Bacakova, Lucie
    Zarubova, Jana
    Travnickova, Martina
    Musilkova, Jana
    Pajorova, Julia
    Slepicka, Petr
    Kasalkova, Nikola Slepickova
    Svorcik, Vaclav
    Kolska, Zdenka
    Motarjemi, Hooman
    Molitor, Martin
    [J]. BIOTECHNOLOGY ADVANCES, 2018, 36 (04) : 1111 - 1126
  • [6] Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing
    Bai, Que
    Han, Kai
    Dong, Kai
    Zheng, Caiyun
    Zhang, Yanni
    Long, Qianfa
    Lu, Tingli
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 9717 - 9743
  • [7] Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods
    Baranyai, Tamas
    Herczeg, Kata
    Onodi, Zsofia
    Voszka, Istvan
    Modos, Karoly
    Marton, Nikolett
    Nagy, Gyoergy
    Maeger, Imre
    Wood, Matthew J.
    El Andaloussi, Samir
    Palinkas, Zoltan
    Kumar, Vikas
    Nagy, Pater
    Kittel, Agnes
    Buzas, Edit Iren
    Ferdinandy, Peter
    Giricz, Zoltan
    [J]. PLOS ONE, 2015, 10 (12):
  • [8] Using exosomes, naturally-equipped nanocarriers, for drug delivery
    Batrakova, Elena V.
    Kim, Myung Soo
    [J]. JOURNAL OF CONTROLLED RELEASE, 2015, 219 : 396 - 405
  • [9] Factors affecting lifespan following below-knee amputation in diabetic patients
    Beyaz, Salih
    Guler, Umit Ozgur
    Bagir, Gulay Simsek
    [J]. ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, 2017, 51 (05) : 393 - 397
  • [10] Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing
    Boniakowski, Anna E.
    Kimball, Andrew S.
    Jacobs, Benjamin N.
    Kunkel, Steven L.
    Gallagher, Katherine A.
    [J]. JOURNAL OF IMMUNOLOGY, 2017, 199 (01) : 17 - 24
12345678910