Challenges in IBD Research 2024: Precision Medicine

被引:11
作者
Syed, Sana [1 ,6 ]
Boland, Brigid S. [2 ]
Bourke, Lauren T. [3 ]
Chen, Lea Ann [4 ]
Churchill, Laurie [5 ]
Dobes, Angela [6 ]
Greene, Adam
Heller, Caren [6 ]
Jayson, Christina
Kostiuk, Benjamin [6 ]
Moss, Alan [6 ,13 ]
Najdawi, Fedaa [7 ]
Plung, Lori [6 ]
Rioux, John D. [8 ]
Rosen, Michael J. [9 ]
Torres, Joana [10 ,11 ]
Zulqarnain, Fatima
Satsangi, Jack [12 ]
机构
[1] Univ Virginia, Dept Pediat, Charlottesville, VA USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA USA
[3] AstraZeneca, Precis Med Drug Dev Early Resp & Immunol, Boston, MA USA
[4] Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Gastroenterol, New Brunswick, NJ USA
[5] Leona M & Harry B Helmsley Charitable Trust, New York, NY USA
[6] Crohns & Colitis Fdn, New York, NY USA
[7] PathAI, Boston, MA USA
[8] Univ Montreal, Montreal Heart Inst, Res Ctr, Montreal, PQ, Canada
[9] Stanford Univ, Sch Med, Dept Pediat, Div Pediat Gastroenterol, Stanford, CA USA
[10] Hosp Beatriz Angelo, Hosp Luz, Div Gastroenterol, Lisbon, Portugal
[11] Univ Lisbon, Fac Med, Lisbon, Portugal
[12] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Translat Gastroenterol Unit,Expt Med Div, Oxford, England
[13] 733 3rd Ave,Suite 510, New York, NY 10017 USA
关键词
precision medicine; biomarkers; INFLAMMATORY-BOWEL-DISEASE; PRIMARY SCLEROSING CHOLANGITIS; CROHNS-DISEASE; ULCERATIVE-COLITIS; NEURAL-NETWORK; ANTI-TNF; INTESTINAL PERMEABILITY; VALIDATION; BIOMARKERS; MANAGEMENT;
D O I
10.1093/ibd/izae084
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024 research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and pragmatic clinical research. Building on Challenges in IBD Research 2019, the current Challenges aims to provide a comprehensive overview of current gaps in inflammatory bowel diseases (IBDs) research and deliver actionable approaches to address them with a focus on how these gaps can lead to advancements in interception, remission, and restoration for these diseases. The document is the result of multidisciplinary input from scientists, clinicians, patients, and funders, and represents a valuable resource for patient-centric research prioritization. In particular, the precision medicine section is focused on the main research gaps in elucidating how to bring the best care to the individual patient in IBD. Research gaps were identified in biomarker discovery and validation for predicting disease progression and choosing the most appropriate treatment for each patient. Other gaps were identified in making the best use of existing patient biosamples and clinical data, developing new technologies to analyze large datasets, and overcoming regulatory and payer hurdles to enable clinical use of biomarkers. To address these gaps, the Workgroup suggests focusing on thoroughly validating existing candidate biomarkers, using best-in-class data generation and analysis tools, and establishing cross-disciplinary teams to tackle regulatory hurdles as early as possible. Altogether, the precision medicine group recognizes the importance of bringing basic scientific biomarker discovery and translating it into the clinic to help improve the lives of IBD patients. Precision medicine is the practice of getting the most suitable drug or treatment option to each individual patient at the right time. In Crohn's disease and ulcerative colitis, we need to learn more about the diversity of patients to deliver precision medicine.
引用
收藏
页码:S39 / S54
页数:16
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