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Protium spruceanum Extract Enhances Mupirocin Activity When Combined with Nanoemulsion-Based Hydrogel: A Multi-Target Strategy for Treating Skin and Soft Tissue Infections
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Amparo, Tatiane Roquete
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Sousa, Lucas Resende Dutra
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Xavier, Viviane Flores
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Seibert, Janaina Brandao
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Univ Sao Paulo, ESALQ, Lab Pathol & Microbial Control, BR-13418900 Piracicaba, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Paiva, Debora Luiza
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

da Silva, Debora dos Santos
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Teixeira, Luiz Fernando de Medeiros
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Univ Fed Ouro Preto, Dept Clin Anal, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

dos Santos, Orlando David Henrique
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Vieira, Paula Melo de Abreu
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Univ Fed Ouro Preto, Dept Biol Sci, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

de Souza, Gustavo Henrique Bianco
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil

Brandao, Geraldo Celio
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Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil
机构:
[1] Univ Fed Ouro Preto, Dept Pharm, BR-35400000 Ouro Preto, Brazil
[2] Univ Sao Paulo, ESALQ, Lab Pathol & Microbial Control, BR-13418900 Piracicaba, Brazil
[3] Univ Fed Ouro Preto, Dept Clin Anal, BR-35400000 Ouro Preto, Brazil
[4] Univ Fed Ouro Preto, Dept Biol Sci, BR-35400000 Ouro Preto, Brazil
关键词:
SSTIs;
antibacterial;
nanoemulsion-based hydrogel;
Protium spruceanum;
synergistic activity;
RESISTANT STAPHYLOCOCCUS-AUREUS;
IN-VITRO;
ANTIMICROBIAL ACTIVITY;
ANTIBACTERIAL ACTIVITY;
ESSENTIAL OILS;
EFFICACY;
ANTIBIOTICS;
BIOFILM;
NANOPARTICLES;
ANTIOXIDANT;
D O I:
10.3390/pharmaceutics16060700
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The treatment of skin and soft tissue infections (SSTIs) can be challenging due to bacterial resistance, particularly from strains like MRSA and biofilm formation. However, combining conventional antibiotics with natural products shows promise in treating SSTIs. The objective of this study is to develop a nanoemulsion-based hydrogel containing Protium spruceanum extract and mupirocin and evaluate its potential for the treatment of SSTIs. The nanoemulsion was obtained by phase inversion and subsequently characterized. The antibacterial activity was evaluated in vitro against S. aureus MRSA, including the synergism of the combination, changes in membrane permeability using flow cytometry, and the anti-biofilm effect. In addition, the irritative potential was evaluated by the HET-CAM assay. The combination exhibited synergistic antibacterial activity against S. aureus and MRSA due to the extract enhancing membrane permeability. The hydrogel demonstrated suitable physicochemical properties, inhibited biofilm formation, and exhibited low irritation. The formulation was nanometric (176.0 +/- 1.656 nm) and monodisperse (polydispersity index 0.286 +/- 0.011). It exhibited a controlled release profile at 48 h and high encapsulation efficacy (94.29 +/- 4.54% for quercitrin and 94.20 +/- 5.44% for mupirocin). Therefore, these findings suggest that the hydrogel developed could be a safe and effective option for treating SSTIs.
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