Exosomes in the Diagnosis of Neuropsychiatric Diseases: A Review

被引：5
作者：
Wu, Song [1 ,2 ,3 ]
Shang, Xinmiao [1 ,2 ,3 ]
Guo, Meng [1 ,2 ,3 ]
Su, Lei [4 ]
Wang, Jun [1 ,2 ,3 ]
机构：
[1] Hubei Univ Technol, Autism & Depress Diag & Intervent Inst, Wuhan 430068, Peoples R China
[2] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Hubei Key Lab Ind Microbiol, Wuhan 430068, Peoples R China
[3] Hubei Univ Technol, Cooperat Innovat Ctr Ind Fermentat, Minist Educ & Hubei Prov, Wuhan 430068, Peoples R China
[4] Shenzhen Univ, Med Sch, Sch Biomed Engn, Shenzhen Key Lab Nanobiosensing Technol,Marshall L, Shenzhen 518060, Peoples R China
来源：
BIOLOGY-BASEL | 2024年 / 13卷 / 06期
基金：
中国国家自然科学基金;
关键词：
exosome; neuropsychiatric disease; diagnosis; central nervous system disease; EXTRACELLULAR VESICLES; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; PLASMA EXOSOMES; ALPHA-SYNUCLEIN; PROTEIN; SCHIZOPHRENIA; BIOMARKERS; BRAIN; TAU;
D O I：
10.3390/biology13060387
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Simple Summary The diagnostic value of exosomes has been well recognized by researchers. The use of exosomal biomarkers as an adjunct diagnosis method not only improves diagnostic accuracy but can also be used for early diagnosis and disease progression differentiation, thus supporting personalized clinical treatment strategies for patients with neuropsychiatric disorders. In this paper, we summarize potential exosomal biomarkers in the diagnosis of neuropsychiatric diseases.Abstract Exosomes are 30-150 nm small extracellular vesicles (sEVs) which are highly stable and encapsulated by a phospholipid bilayer. Exosomes contain proteins, lipids, RNAs (mRNAs, microRNAs/miRNAs, long non-coding RNAs/lncRNAs), and DNA of their parent cell. In pathological conditions, the composition of exosomes is altered, making exosomes a potential source of biomarkers for disease diagnosis. Exosomes can cross the blood-brain barrier (BBB), which is an advantage for using exosomes in the diagnosis of central nervous system (CNS) diseases. Neuropsychiatric diseases belong to the CNS diseases, and many potential diagnostic markers have been identified for neuropsychiatric diseases. Here, we review the potential diagnostic markers of exosomes in neuropsychiatric diseases and discuss the potential application of exosomal biomarkers in the early and accurate diagnosis of these diseases. Additionally, we outline the limitations and future directions of exosomes in the diagnosis of neuropsychiatric diseases.
引用
收藏
页数：20
相关论文
共 168 条
[1]   Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis [J].
Androutsou, Maria-Eleni ;
Tapeinou, Anthi ;
Vlamis-Gardikas, Alexios ;
Tselios, Theodore .
MEDICINAL CHEMISTRY, 2018, 14 (02) :120-128
[2]   Proteome profiling of neuron-derived exosomes in Alzheimer's disease reveals hemoglobin as a potential biomarker [J].
Arioz, Burak Ibrahim ;
Tufekci, Kemal Ugur ;
Olcum, Melis ;
Durur, Devrim Yagmur ;
Akarlar, Busra A. ;
Ozlu, Nurhan ;
Bagriyanik, H. Alper ;
Keskinoglu, Pembe ;
Yener, Gorsev ;
Genc, Sermin .
NEUROSCIENCE LETTERS, 2021, 755
[3]   Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome [J].
Ashwood, Paul ;
Krakowiak, Paula ;
Hertz-Picciotto, Irva ;
Hansen, Robin ;
Pessah, Isaac ;
Van de Water, Judy .
BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (01) :40-45
[4]   Dysregulation of Th17 and Treg cells in autoimmune diseases [J].
Astier, Anne L. ;
Kofler, David M. .
FRONTIERS IN IMMUNOLOGY, 2023, 14
[5]   The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders [J].
Aziz, Faisal .
CELLULAR IMMUNOLOGY, 2016, 303 :1-6
[6]   Intra-individual variability in the neuroprotective and promyelinating properties of conditioned culture medium obtained from human adipose mesenchymal stromal cells [J].
Baldassarro, Vito Antonio ;
Perut, Francesca ;
Cescatti, Maura ;
Pinto, Valentina ;
Fazio, Nicola ;
Alastra, Giuseppe ;
Parziale, Valentina ;
Bassotti, Alessandra ;
Fernandez, Mercedes ;
Giardino, Luciana ;
Baldini, Nicola ;
Calza, Laura .
STEM CELL RESEARCH & THERAPY, 2023, 14 (01)
[7]   Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients [J].
Banigan, Meredith G. ;
Kao, Patricia F. ;
Kozubek, James A. ;
Winslow, Ashley R. ;
Medina, Juan ;
Costa, Joan ;
Schmitt, Andrea ;
Schneider, Anja ;
Cabral, Howard ;
Cagsal-Getkin, Ozge ;
Vanderburg, Charles R. ;
Delalle, Ivana .
PLOS ONE, 2013, 8 (01)
[8]   Specific Signatures of Serum miRNAs as Potential Biomarkers to Discriminate Clinically Similar Neurodegenerative and Vascular-Related Diseases [J].
Barbagallo, Cristina ;
Mostile, Giovanni ;
Baglieri, Gloriangela ;
Giunta, Flavia ;
Luca, Antonina ;
Raciti, Loredana ;
Zappia, Mario ;
Purrello, Michele ;
Ragusa, Marco ;
Nicoletti, Alessandra .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2020, 40 (04) :531-546
[9]  
Barger SW, 1997, J NEUROCHEM, V69, P60
[10]   Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish [J].
Baronio, Diego ;
Chen, Yu-Chia ;
Decker, Amanda R. ;
Enckell, Louise ;
Fernandez-Lopez, Blanca ;
Semenova, Svetlana ;
Puttonen, Henri A. J. ;
Cornell, Robert A. ;
Panula, Pertti .
ACTA PHYSIOLOGICA, 2022, 234 (01)
12345678910