Allogeneic Hematopoietic Stem Cell Transplantation for Mature T/NK-Cell Lymphomas in Children

Mature T/NK-cell lymphomas (MTCLs) are a heterogeneous group of lymphoproliferative disorders, relatively rare in adults and children. Allogeneic hematopoietic stem cell transplantation (HSCT) can be considered in some cases as a consolidation and is the first choice for refractory forms and relapses. We retrospectively analyzed 19 pediatric patients with MTCL who received allogeneic hematopoietic stem cell transplantation from a haploidentical or unrelated donor on the a# T cell depletion platform. Among the studied patients, cutaneous Tcell lymphoma was diagnosed in 5, hepatosplenic gd T-cell lymphoma in 4, ALK-positive anaplastic large cell lymphoma in 9 patients, and 1 had nasal T/NK cell lymphoma. All patients received myeloablative conditioning based on treosulfan or total body irradiation. Non -relapse mortality was 5%, the cumulative incidence of relapse or progression at 5 years was 27%, 5year event -free survival was 67%, and 5 -year overall survival was 78%. Thus, our data support that allogeneic a# T -cell -depleted HSCT can provide long-term overall survival of children with high -risk mature T -cell lymphomas. (c) 2024 The American Society for Transplantation and Cellular Therapy.