Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health

被引：5

作者：

Bellamy, Christopher O. C. ^{[1
,2
]}

O'Leary, Jacqueline G. ^{[3
,4
]}

Adeyi, Oyedele ^{[5
]}

Baddour, Nahed ^{[6
]}

Batal, Ibrahim ^{[7
]}

Bucuvalas, John ^{[8
]}

Del Bello, Arnaud ^{[9
]}

El Hag, Mohamed ^{[10
]}

El-Monayeri, Magda ^{[11
]}

Farris, Alton B., III ^{[12
]}

Feng, Sandy ^{[11
]}

Fiel, Maria Isabel ^{[13
]}

Fischer, Sandra E. ^{[14
]}

Fung, John ^{[15
]}

Grzyb, Krzysztof ^{[16
]}

Guimei, Maha ^{[17
]}

Haga, Hironori ^{[18
]}

Hart, John ^{[19
]}

Jackson, Annette M. ^{[20
]}

Jaeckel, Elmar ^{[21
]}

Khurram, Nigar A. ^{[22
]}

Knechtle, Stuart J. ^{[20
]}

Lesniak, Drew ^{[22
]}

Levitsky, Josh ^{[23
]}

Mccaughan, Geoff ^{[24
]}

Mckenzie, Catriona ^{[25
]}

Mescoli, Claudia ^{[26
]}

Miquel, Rosa ^{[27
]}

Minervini, Marta I. ^{[22
]}

Nasser, Imad Ahmad ^{[28
]}

Neil, Desley ^{[29
]}

O'Neil, Maura F. ^{[30
]}

Pappo, Orit ^{[31
]}

Randhawa, Parmjeet ^{[22
]}

Ruiz, Phillip ^{[32
]}

Fueyo, Alberto Sanchez ^{[27
]}

Schady, Deborah ^{[33
]}

Schiano, Thomas ^{[34
]}

Sebagh, Mylene ^{[35
]}

Smith, Maxwell ^{[36
]}

Stevenson, Heather L. ^{[37
]}

Taner, Timucin ^{[38
]}

Taubert, Richard ^{[39
]}

Thung, Swan ^{[13
]}

Trunecka, Pavel ^{[40
]}

Wang, Hanlin L. ^{[41
]}

Wood-Trageser, Michelle ^{[22
]}

Yilmaz, Funda ^{[42
]}

Zen, Yoh ^{[27
]}

Zeevi, Adriana ^{[43
]}

机构：

[1] Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Scotland

[2] Edinburgh Royal Infirm, Dept Pathol, Edinburgh, Scotland

[3] Dallas VA Med Ctr, Dallas Texas, Dallas, TX USA

[4] Univ Texas, Dept Med, Southwestern, Dallas, TX USA

[5] Univ Minnesota, Med Sch, Dept Pathol, Minneapolis, MN USA

[6] Univ Alexandria, Fac Med, Alexandria, Egypt

[7] Columbia Univ, Irving Med Ctr, New York, NY USA

[8] Mt Sinai, Mt Sinai, NY USA

[9] Toulouse Univ Hosp, Toulouse, France

[10] Cleveland Clin, Cleveland, OH USA

[11] Ain Shams Univ, Cairo, Egypt

[12] Emory Univ Hosp, Pathol, Atlanta, GA USA

[13] Icahn Sch Med Mt Sinai, Pathol, Elmhurst, NY USA

[14] Univ Toronto, Pathol, Toronto, ON, Canada

[15] UChicago Med, Dept Pharm, Chicago, IL 60616 USA

[16] Univ Oslo, Oslo, Norway

[17] Armed Forces Coll Med, Cairo, Egypt

[18] Kyoto Univ, Kyoto, Japan

[19] Uchicago Med, Dept Pathol, Chicago, IL USA

[20] Duke Univ, DUMC, Durham, NC USA

[21] Univ Hlth Network, Toronto, ON, Canada

[22] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA

[23] Northwestern Med, Chicago, IL USA

[24] Centenary Inst, Camperdown, NSW, Australia

[25] NSW Govt Hlth, North Sydney, NSW, Australia

[26] Univ Hosp Padova, Padua, Italy

[27] Kings Coll Hosp London, Inst Liver Studies, London, England

[28] Beth Israel Deaconess Med Ctr, Boston, MA USA

[29] Univ Hosp Birmingham NHS Fdn Trust, Birmingham, England

[30] Univ Kansas Med Ctr, Kansas City, KS USA

[31] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel

[32] Univ Miami Hosp, Miami, FL USA

[33] Texas Childrens Hosp, Houston, TX USA

[34] Mt Sinai Med Ctr, Recanati Miller Transplantat Inst, New York, NY 10029 USA

[35] Hosp Paris, Paris, France

[36] Mayo Clin Arizona, Pathol, Scottsdale, AZ USA

[37] UTMB Hlth, Galveston, TX USA

[38] Mayo Clin, Div Transplantat Surg, Rochester, MN USA

[39] Hannover Med Sch, Dept Gastroenterol Hepatol Infect Dis & Endocrinol, Hannover, Germany

[40] Inst Clin & Expt Med IKEM, Prague, Czech Republic

[41] UCLA Hlth, Los Angeles, CA USA

[42] Ege Univ, Dept Pathol, Bornova, Turkiye

[43] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2024年 / 24卷 / 06期

关键词：

Banff classification; liver transplantation; immunosuppression; alloimmunity; T cell-mediated rejection; antibody-mediated rejection; pathology; anatomy; protocol biopsy; NODULAR REGENERATIVE HYPERPLASIA; IDIOPATHIC PORTAL-HYPERTENSION; BILE-DUCT LOSS; TRANSPLANT RECIPIENTS; PROGRESSIVE FIBROSIS; MANAGEMENT; REJECTION; BIOPSIES; RISK;

D O I：

10.1016/j.ajt.2024.03.008

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including noninvasive and tissue monitoring, immunosuppression optimization, and long-term structural changes. Potential revision of the rejection classification scheme to better accommodate and communicate late T cell -mediated rejection patterns and related structural changes, such as nodular regenerative hyperplasia, were discussed. Improved stratification of long-term maintenance immunosuppression to match the heterogeneity of patient settings will be central to improving long-term patient survival. Such personalized therapeutics are in turn contingent on a better understanding and monitoring of allograft status within a rational decision -making approach, likely to be facilitated in implementation with emerging decision -support tools. Proposed revisions to rejection classification emerging from the meeting include the incorporation of interface hepatitis and fibrosis staging. These will be opened to online testing, modified accordingly, and subject to consensus discussion leading up to the next Banff conference.

引用

页码：905 / 917

页数：13

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