Multifunctional Supramolecular Hydrogel Modulated Heterojunction Interface Carrier Transport Engineering Facilitates Sensitive Photoelectrochemical Immunosensing

被引：11

作者：

Leng, Dongquan ^{[1
]}

Yu, Zhen ^{[1
]}

Liu, Jinjie ^{[1
]}

Jin, Weihan ^{[1
]}

Wu, Tingting ^{[1
]}

Ren, Xiang ^{[1
]}

Ma, Hongmin ^{[1
]}

Wu, Dan ^{[1
]}

Ju, Huangxian ^{[1
,2
]}

Wei, Qin ^{[1
,3
]}

机构：

[1] Univ Jinan, Collaborat Innovat Ctr Green Chem Mfg & Accurate D, Key Lab Interfacial React & Sensing Anal Univ Shan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China

[2] Nanjing Univ, Dept Chem, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China

[3] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea

来源：

ANALYTICAL CHEMISTRY | 2024年 / 96卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Conversion efficiency - Electrochemistry - Electrolytes - Heterojunctions - Hydrogels - Light sources - Manganese oxide - Tungsten compounds;

D O I：

10.1021/acs.analchem.4c01416

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Highly responsive interface of semiconductor nanophotoelectrochemical materials provides a broad development prospect for the identification of low-abundance cancer marker molecules. This work innovatively proposes an efficient blank WO3/SnIn4S8 heterojunction interface formed by self-assembly on the working electrode for interface regulation and photoregulation. Different from the traditional biomolecular layered interface, a hydrogel layer containing manganese dioxide with a wide light absorption range is formed at the interface after an accurate response to external immune recognition. The formation of the hydrogel layer hinders the effective contact between the heterojunction interface and the electrolyte solution, and manganese dioxide in the hydrogel layer forms a strong competition between the light source and the substrate photoelectric material. The process effectively improves the carrier recombination efficiency at the interface, reduces the interface reaction kinetics and photoelectric conversion efficiency, and thus provides strong support for target identification. Taking advantage of the process, the resulting biosensors are being explored for sensitive detection of human epidermal growth factor receptor 2, with a limit of detection as low as 0.037 pg/mL. Also, this study contributes to the advancement of photoelectrochemical biosensing technology and opens up new avenues for the development of sensitive and accurate analytical tools in the field of bioanalysis.

引用

页码：8814 / 8821

页数：8

共 40 条

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