Novel synthesis of quinoline chalcone derivatives- Design, synthesis, characterization and antimicrobial activity

被引：6

作者：

Kumar, C. H. Praveen ^{[1
]}

Katagi, Manjunatha S. ^{[2
]}

Nandeshwarappa, B. P. ^{[1
]}

机构：

[1] Davangere Univ, Dept Studies Chem, Davanagere 577007, Karnataka, India

[2] Bapuji Pharm Coll, Dept Pharmaceut Chem, Davangere 577004, Karnataka, India

来源：

CHEMICAL DATA COLLECTIONS | 2022年 / 42卷

关键词：

Antibacterial; Antifungal; 12-Dihydro-1-methyl-2-oxo quinoline-3-carbaldehyde; Chalcones; METHOXYLATED CHALCONES; BIOLOGICAL EVALUATION; ANTICANCER; ANTIMALARIAL; CANDIDATES; SAR;

D O I：

10.1016/j.cdc.2022.100955

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, an easy and conventional method has been adopted for the synthesis of novel 1-methyl-3-(3-oxo-3-phenylprop-1-enyl) quinoline-2-(1H)-ones (5a-i) by a condensation reaction of 1,2-dihydro-1-methyl-2-oxo quinoline-3-carbaldehyde (3) with substituted acetophenones (4a-i) and piperidine in the presence ethanol as a solvent. The structures of all the newly synthesized products were confirmed with their elemental analysis,H-1 NMR, C-13 NMR, FT-IR and mass spectral analysis. All the newly synthesized compounds (5a-i) were screened for in vitro antimicrobial activities (Minimum Inhibitory Concentration (MIC) by agar well diffusion method using gentamycin as positive and DMSO as a negative control. The tested, compounds 5f and 5i exhibited potent activity against S. aureus, B. subtilis, and S. Typhi, P. aeruginosa, where as compound 5a showed promising activity against S. aureus, B. subtilis, and S. Typhi, P. aeruginosa.

引用

页数：10

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