Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions

被引：4

作者：

Liu, Ziwei ^{[1
,2
]}

Jiang, Clancy Zhijian ^{[2
]}

Bond, Andrew D. ^{[3
]}

Tosca, Nicholas J. ^{[2
]}

Sutherland, John D. ^{[1
]}

机构：

[1] MRC Lab Mol Biol, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England

[2] Univ Cambridge, Dept Earth Sci, Downing St, Cambridge CB2 3EQ, England

[3] Univ Cambridge, Yusuf Hamied Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 51期

基金：

英国医学研究理事会;

关键词：

CARBONATE PRECIPITATION; PRECAMBRIAN CARBONATES; LIGASE; WATER; GEOCHEMISTRY; SOLUBILITY; MECHANISM; SEAWATER;

D O I：

10.1039/d4cc01086h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(ii). The mechanism of the activation reaction has been investigated using 5 '-AMP as an analogue.

引用

页码：6528 / 6531

页数：4

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