Stereoselective synthesis of multifunctionalized chiral silacyclopentanes

被引：1

作者：

Kuroo, Akihiro ^{[1
]}

Igawa, Kazunobu ^{[1
,2
,3
,4
]}

Tomooka, Katsuhiko ^{[1
,2
,3
,4
]}

机构：

[1] Kyushu Univ, Interdisciplinary Grad Sch Engn Sci, 6-1 Kasuga Koen, Kasuga, Fukuoka 8168580, Japan

[2] Kumamoto Univ, Fac Adv Sci & Technol, Dept Chem, 2-39-1 Kurokami, Kumamoto 8608555, Japan

[3] Kyushu Univ, Inst Mat Chem & Engn, 6-1 Kasuga Koen, Kasuga, Fukuoka 8168580, Japan

[4] Kyushu Univ, IRCCS, 6-1 Kasuga Koen, Kasuga, Fukuoka 8168580, Japan

来源：

CHEMISTRY LETTERS | 2024年 / 53卷 / 03期

关键词：

asymmetric synthesis; chiral silacyclopentanes; chiral silicon molecule; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; SILICON; MIGRATION; CARBON;

D O I：

10.1093/chemle/upae039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized multifunctionalized silacyclopentanes in a highly selective manner from enantioenriched silacyclopentenol, which is readily accessible from achiral silacyclopentene oxide by enantioselective beta-elimination. Functionalization at C2, C4, and C5 positions of silacyclopentenol was achieved based on the regio- and stereoselective nucleophilic substitution reaction of epoxides. We have synthesized multifunctionalized silacyclopentanes in a highly selective manner from enantioenriched silacyclopentenol, which is readily accessible from achiral silacyclopentene oxide by enantioselective beta-elimination. Functionalization at C2, C4, and C5 positions of silacyclopentenol was achieved based on the regio- and stereoselective nucleophilic substitution reaction of epoxides.

引用

页数：4

共 20 条

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