Immune checkpoint inhibitor therapy associated with IgA nephropathy: a case report and literature review

被引：2

作者：

Chabannes, Melchior ^{[1
,2
]}

Lisri, Ziriab ^{[1
]}

Lang, Stephane ^{[1
]}

Seibel, Jean ^{[1
]}

Eberst, Guillaume ^{[2
,3
]}

Ducloux, Didier ^{[1
,2
]}

Pursun, Celine ^{[1
]}

Durey, Marie Agnes Dragon ^{[4
,5
,6
]}

Alyanakia, Marie-Alexandra ^{[7
]}

Felix, Sophie ^{[8
]}

Crepin, Thomas ^{[1
,2
]}

机构：

[1] Univ Hosp, Dept Nephrol Dialysis & Renal Transplantat, Besancon, France

[2] Univ Franche Comte, CHU Besancon, EFS, INSERM,UMR RIGHT, Besancon, France

[3] Univ Hosp, Dept Pneumol, Besancon, France

[4] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Biol Immunol, Paris, France

[5] Cordelier Res Ctr, INSERM, UMRS 1138, Paris, France

[6] Univ Paris Cite, Paris, France

[7] Univ Paris, Hop Necker Enfants Malades, Assistance Publ Hop Paris AP HP, Hematol Dept,Serv Immunol Biol, Paris, France

[8] Univ Hosp, Dept Pathol, Besancon, France

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

IgA nephropathy; IgAN; immune check inhibitor (ICI); pembrolizumab; glomerulonephritis; immune-related adverse events (IRAE); AKI (acute kidney injury); NIVOLUMAB THERAPY; VASCULITIS;

D O I：

10.3389/fimmu.2024.1393901

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune checkpoint inhibitors (ICIs) dramatically improve the prognosis of many malignancies but at the cost of numerous side effects, which may limit their benefits. Acute kidney injury associated with immune checkpoint inhibitors most frequently are acute tubulointerstitial nephritis (ATIN), but various cases of glomerulonephritis have also been reported. Herein, we report a case of severe IgA nephropathy (IgAN) associated with ICIs and carry out a literature review. IgAN was diagnosed in a median time of 5 months (range 1-12 months) after the initiation of ICIs, with heterogeneous severity, and usually treated by corticosteroid and discontinuation of ICIs. In contrast to our case, renal outcomes in literature were often favorable, with recovery of renal function and a reduction in proteinuria on treatment. Although IgAN related to ICIs is a much rarer complication than ATIN, it may still be underdiagnosed. Careful questioning and screening for asymptomatic hematuria should be performed before using ICIs.

引用

页数：7

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