Arnicolide D: a multi-targeted anticancer sesquiterpene lactone-preclinical efficacy and mechanistic insights

被引：4

作者：

Mangalpady, Shivaprasad Shetty ^{[1
]}

Pena-Corona, Sheila I. ^{[2
]}

Borbolla-Jimenez, Fabiola ^{[2
]}

Kaverikana, Rajesh ^{[3
]}

Shetty, Shobhitha ^{[4
]}

Shet, Vinayaka Babu ^{[5
]}

Almarhoon, Zainab M. ^{[6
]}

Calina, Daniela ^{[7
]}

Leyva-Gomez, Gerardo ^{[2
]}

Sharifi-Rad, Javad ^{[8
]}

机构：

[1] Nitte, NMAM Inst Technol NMAMIT, Dept Chem, Mangaluru, India

[2] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico CIty 04510, Mexico

[3] Nitte, NGSM Inst Pharmaceut, Dept Pharmacol, Mangaluru, India

[4] AJ Inst Engn & Technol, Dept Chem, Mangaluru, India

[5] Nitte, NMAM Inst Technol NMAMIT, Dept Biotechnol Engn, Nitte, India

[6] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia

[7] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania

[8] Univ Azuay, Fac Med, Cuenca, Ecuador

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2024年 / 397卷 / 09期

基金：

英国科研创新办公室;

关键词：

Centipeda minima; Arnicolide D; Anti-cancer mechanisms; Apoptosis; PI3K/AKT/mTOR pathway; Sesquiterpene lactone; Src degradation; CELL-PROLIFERATION; CENTIPEDA-MINIMA; ARNICA-MONTANA; CANCER; CONSTITUENTS; INHIBITION; PATHWAY; GROWTH;

D O I：

10.1007/s00210-024-03095-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Arnicolide D, a potent sesquiterpene lactone from Centipeda minima, has emerged as a promising anticancer candidate, demonstrating significant efficacy in inhibiting cancer cell proliferation, inducing apoptosis, and suppressing metastasis across various cancer models. This comprehensive study delves into the molecular underpinnings of Arnicolide D's anticancer actions, emphasizing its impact on key signaling pathways such as PI3K/AKT/mTOR and STAT3, and its role in modulating cell cycle and survival mechanisms. Quantitative data from preclinical studies reveal Arnicolide D's dose-dependent cytotoxicity against cancer cell lines, including nasopharyngeal carcinoma, triple-negative breast cancer, and human colon carcinoma, showcasing its broad-spectrum anticancer potential. Given its multifaceted mechanisms and preclinical efficacy, Arnicolide D warrants further investigation in clinical settings to validate its therapeutic utility against cancer. The evidence presented underscores the need for rigorous pharmacokinetic and toxicological studies to establish safe dosing parameters for future clinical trials.

引用

页码：6317 / 6336

页数：20

共 92 条

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