A brief history of clozapine use in Taiwan

被引：1

作者：

Lin, Shih-Ku ^{[1
,2
]}

Lane, Hsien-Yuan ^{[3
,4
,5
]}

机构：

[1] Linkou Chang Gung Mem Hosp, Taoyuan, Taiwan

[2] Taipei City Hosp & Psychiat Ctr, Taipei, Taiwan

[3] China Med Univ Hosp, Brain Dis Res Ctr, Dept Psychiat, Taichung, Taiwan

[4] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[5] Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan

来源：

SCHIZOPHRENIA RESEARCH | 2024年 / 268卷

关键词：

Clotiapine; Fluvoxamine; Obsessive compulsive symptoms; Bone mineral density; Bipolar disorder; Pneumonia; ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER; HOMOVANILLIC-ACID; RESPONSE CURVES; RECEPTOR; PNEUMONIA; PLASMA; SCHIZOPHRENIA; FLUVOXAMINE; RISK;

D O I：

10.1016/j.schres.2023.06.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Blood concentrations of clozapine in Taiwanese patients appeared approximately 30-50 % higher than that from Caucasian patients, and women possessed a higher blood levels. Fluvoxamine was reported to increase the clozapine levels, reduce clozapine-related weight gain and metabolic disturbances, and improved general psychopathology. Clothiapine, a chemical structure analogue of clozapine, showed potential of benefitting patients who are unsuitable for clozapine treatment in Taiwan. Obsessive/compulsive symptom (OCS) is a common side effect of clozapine. Concentrations of clozapine were remarkably higher in patients with OCS than in those without. In conclusion, clozapine is a widely used in patients with schizophrenia in Taiwan.

引用

页码：34 / 37

页数：4

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