A brief history of clozapine use in Taiwan

被引：1

作者：

Lin, Shih-Ku ^{[1
,2
]}

Lane, Hsien-Yuan ^{[3
,4
,5
]}

机构：

[1] Linkou Chang Gung Mem Hosp, Taoyuan, Taiwan

[2] Taipei City Hosp & Psychiat Ctr, Taipei, Taiwan

[3] China Med Univ Hosp, Brain Dis Res Ctr, Dept Psychiat, Taichung, Taiwan

[4] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[5] Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan

来源：

SCHIZOPHRENIA RESEARCH | 2024年 / 268卷

关键词：

Clotiapine; Fluvoxamine; Obsessive compulsive symptoms; Bone mineral density; Bipolar disorder; Pneumonia; ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER; HOMOVANILLIC-ACID; RESPONSE CURVES; RECEPTOR; PNEUMONIA; PLASMA; SCHIZOPHRENIA; FLUVOXAMINE; RISK;

D O I：

10.1016/j.schres.2023.06.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Blood concentrations of clozapine in Taiwanese patients appeared approximately 30-50 % higher than that from Caucasian patients, and women possessed a higher blood levels. Fluvoxamine was reported to increase the clozapine levels, reduce clozapine-related weight gain and metabolic disturbances, and improved general psychopathology. Clothiapine, a chemical structure analogue of clozapine, showed potential of benefitting patients who are unsuitable for clozapine treatment in Taiwan. Obsessive/compulsive symptom (OCS) is a common side effect of clozapine. Concentrations of clozapine were remarkably higher in patients with OCS than in those without. In conclusion, clozapine is a widely used in patients with schizophrenia in Taiwan.

引用

页码：34 / 37

页数：4

共 66 条

[1] Clozapine and risk of pneumonia [J].

Abdelmawla, Nasser ;

Ahmed, Magdi I. .

BRITISH JOURNAL OF PSYCHIATRY, 2009, 194 (05) :468-469

[2] CLOZAPINE - PHARMACOKINETIC INVESTIGATIONS AND BIOCHEMICAL EFFECTS IN MAN [J].

ACKENHEIL, M .

PSYCHOPHARMACOLOGY, 1989, 99 :S32-S37

[3] Antipsychotic medications and the progression of upper respiratory infection to pneumonia in patients with schizophrenia [J].

Chang, Chi-Kang ;

Chen, Pao-Huan ;

Pan, Chun-Hung ;

Su, Sheng-Shiang ;

Tsai, Shang-Ying ;

Chen, Chiao-Chicy ;

Kuo, Chian-Jue .

SCHIZOPHRENIA RESEARCH, 2020, 222 :327-334

[4]

Chang WH, 1997, J FORMOS MED ASSOC, V96, P599

[5]

CHANG WH, 1988, PSYCHOPHARMACOLOGY, V95, P459

[6]

CHANG WH, 1987, PSYCHOPHARMACOLOGY, V93, P403

[7] DETERMINATION OF CLOZAPINE AND DESMETHYLCLOZAPINE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET DETECTION [J].

CHUNG, MC ;

LIN, SK ;

CHANG, WH ;

JANN, MW .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 613 (01) :168-173

[8] The history of clozapine and its emergence in the US market: a review and analysis [J].

Crilly, John .

HISTORY OF PSYCHIATRY, 2007, 18 (01) :39-60

[9] The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs:: is M1 agonism a pre-requisite for mimicking clozapine's actions? [J].

Davies, MA ;

Compton-Toth, BA ;

Hufeisen, SJ ;

Meltzer, HY ;

Roth, BL .

PSYCHOPHARMACOLOGY, 2005, 178 (04) :451-460

[10]

de Leon Jose, 2022, Psychiatr Danub, V34, P411, DOI 10.24869/psyd.2022.411

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