SYNTHESIS OF BIOACTIVE HETEROCYCLIC COMPOUNDS USING CAMPHOR

被引：2

作者：

Alwan, Ensaf Sultan ^{[1
]}

Mohareb, Rafat Milad ^{[2
]}

机构：

[1] Future Univ Egypt, Fac Pharmaceut Sci Pharmaceut Ind, Dept Pharmaceut Chem, Cairo, Egypt

[2] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2024年 / 38卷 / 04期

关键词：

Anti-microbial; Camphor; Heterocyclic; Pyrazol-3(2H)-one; Thiazol-4(5H)-one; Thieno[3,2-d]thiazole; Xanthenes; MULTICOMPONENT REACTIONS; THIAZOLE; DERIVATIVES; KINASE; INHIBITORS; ANTITUMOR; ANALOGS;

D O I：

10.4314/bcse.v38i4.20

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aim of the work was to synthesize novel heterocyclic compounds derived from camphor with antibacterial activity. The pyridazine, xanthene, pyranothiazole, pyridinothiazole, thiophene and pyrazole derivatives were produced from 4,11,11-trimethyl-9-phenyl-7-(2-phenylhydrazono)-3,4,5,6,7,9-hexahydro-1H-1,4-methanoxanthen-8(2H)-one (1). Thiophene derivatives 6a,b were produced according to the Gewald's reaction for thiophene synthesis. On the other hand, pyranothiazol derivatives 8a, b were synthesized by the multicomponent reactions between xanthene derivative 5, benzaldehyde and ethylcyanoacetate or malononitrile in ethanol/triethylamine. Whereas, pyridinothiazole derivative 9 was produced in ethanol/ammonium acetate by the multicomponent reaction between xanthene derivative 5, benzaldehyde and malononitrile. The antibacterial activity of the synthesized compounds was evaluated against E. coli bacteria. All synthesized compounds showed moderate activity against E. coli bacteria.

引用

页码：1069 / 1076

页数：8

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