Comparison of Mir122 expression in children with biliary atresia and healthy group

被引：0

作者：

Motazedian, Nasrin ^{[1
]}

Azarpira, Negar ^{[1
]}

Falamarzi, Kimia ^{[2
]}

Dehghani, Seyed Mohsen ^{[1
]}

Ataollahi, Maryam ^{[1
]}

Esfandiari, Elaheh ^{[1
]}

Dara, Mahintaj ^{[3
]}

Toobafard, Razieh ^{[1
]}

Sayadi, Mehrab ^{[4
]}

Shekarforoush, Seyed Ali ^{[1
]}

Owji, Seyed Hossein ^{[2
,5
]}

Malekhosseini, Seyed Ali ^{[6
]}

机构：

[1] Shiraz Univ Med Sci, Transplant Res Ctr, Shiraz, Iran

[2] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[3] Shiraz Univ Med Sci, Stem Cells Technol Res Ctr, Shiraz, Iran

[4] Shiraz Univ Med Sci, Cardiovasc Res Ctr, Shiraz, Iran

[5] Shiraz Univ Med Sci, Otolaryngol Res Ctr, Dept Otolaryngol, Shiraz, Iran

[6] Shiraz Univ Med Sci, Abu Ali Sina Organ Transplant Ctr, Shiraz, Iran

来源：

MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS | 2024年 / 13卷 / 03期

关键词：

Micro RNA; miR-122; Biliary atresia; Liver; LIVER-DISEASE; CIRCULATING MICRORNA; IDENTIFICATION; MIR-122; INJURY;

D O I：

10.22099/mbrc.2024.49649.1950

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biliary atresia (BA) is the primary cause of neonatal jaundice with various pathological mechanisms. Many BA patients may experience progressive liver dysfunction and eventually need a liver transplant. Therefore, identifying potential non-invasive biomarkers for BA is crucial. miR-122, the most abundant microRNA in the liver, plays significant roles in different liver diseases. This study aimed to assess miR-122 levels in BA patients. Eighteen patients with biliary atresia were selected at random from the Shiraz Pediatric Liver Cirrhosis Cohort Study (SPLCCS), along with 18 healthy controls. Blood samples were collected, and biochemical parameters (such as liver function tests) were measured. Quantitative reverse-transcription PCR (RT-PCR) was conducted on serum samples from both the case and control groups to analyze miR-122 levels. The study results indicated that serum miR-122 expression in BA patients was elevated compared to the control group, although it did not reach statistical significance. Additionally, no correlation was found between miR-122 expression and serum levels of liver enzymes or other laboratory findings in BA cases. miR-122 could be a potential target for diagnosing BA; however, further research with a larger population is necessary to determine if miR-122 could serve as a useful biomarker for diagnosing BA.

引用

页码：147 / 154

页数：8

共 33 条

[1] miR33a/miR33b*and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease [J].