Exploring the Immunological Profile in Breast Cancer: Recent Advances in Diagnosis and Prognosis through Circulating Tumor Cells

被引:5
作者
Kotsifaki, Amalia [1 ]
Maroulaki, Sousanna [1 ]
Armakolas, Athanasios [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Med Sch, Physiol Lab, Athens 11527, Greece
基金
英国科研创新办公室;
关键词
breast cancer; circulating tumor cells (CTCs); cancer diagnosis; cancer prognosis; immunological profile; immunological biomarkers; clinical application; MOLECULAR SUBTYPES; FLOW-CYTOMETRY; LIQUID BIOPSY; MECHANISMS; EXPRESSION; BIOMARKERS; GUIDELINES; ENRICHMENT; CLUSTERS; DETECT;
D O I
10.3390/ijms25094832
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review offers a comprehensive exploration of the intricate immunological landscape of breast cancer (BC), focusing on recent advances in diagnosis and prognosis through the analysis of circulating tumor cells (CTCs). Positioned within the broader context of BC research, it underscores the pivotal role of the immune system in shaping the disease's progression. The primary objective of this investigation is to synthesize current knowledge on the immunological aspects of BC, with a particular emphasis on the diagnostic and prognostic potential offered by CTCs. This review adopts a thorough examination of the relevant literature, incorporating recent breakthroughs in the field. The methodology section succinctly outlines the approach, with a specific focus on CTC analysis and its implications for BC diagnosis and prognosis. Through this review, insights into the dynamic interplay between the immune system and BC are highlighted, with a specific emphasis on the role of CTCs in advancing diagnostic methodologies and refining prognostic assessments. Furthermore, this review presents objective and substantiated results, contributing to a deeper understanding of the immunological complexity in BC. In conclusion, this investigation underscores the significance of exploring the immunological profile of BC patients, providing valuable insights into novel advances in diagnosis and prognosis through the utilization of CTCs. The objective presentation of findings emphasizes the crucial role of the immune system in BC dynamics, thereby opening avenues for enhanced clinical management strategies.
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页数:27
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