Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia

被引:0
作者
Kaninia, Stefania [1 ]
Mccarthy, Rosaleen A. [1 ]
Saad, Zia [2 ]
Pengas, George P. [1 ]
机构
[1] Univ Hosp Southampton NHS Fdn Trust, Wessex Neurol Ctr, Southampton SO16 6YD, England
[2] Univ Hosp Southampton NHS Fdn Trust, Dept Nucl Med, Southampton, England
关键词
Dementia with Lewy Bodies; apathy; alexithymia; young-onset dementia; DISEASE;
D O I
10.1080/13554794.2024.2354545
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A diagnosis of young-onset dementia can pose a significant challenge for the clinician. We present a young patient with a very unusual presentation of Dementia with Lewy Bodies. The lack of motor symptoms and his marked apathy delayed his diagnosis. His symptoms were thought to be due to depression based on normal structural imaging and the psychiatric nature of his presentation. An extensive work-up was performed. Evidence of a structural neurodegenerative process was provided by the HMPAO-SPECT. Cardiac MIBG confirmed the diagnosis.
引用
收藏
页码:191 / 194
页数:4
相关论文
共 12 条
[1]   Alexithymia in Parkinson's disease: A systematic review of the literature [J].
Assogna, Francesca ;
Cravello, Luca ;
Orfei, Maria Donata ;
Cellupica, Nystya ;
Caltagirone, Carlo ;
Spalletta, Gianfranco .
PARKINSONISM & RELATED DISORDERS, 2016, 28 :1-11
[2]   Behavioral and psychological symptoms in dementia with Lewy-bodies (DLB): Frequency and relationship with disease severity and motor impairment [J].
Borroni, B. ;
Agosti, C. ;
Padovani, A. .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2008, 46 (01) :101-106
[3]   Apathy is associated with faster global cognitive decline and early nursing home admission in dementia with Lewy bodies [J].
Breitve, Monica H. ;
Bronnick, Kolbjorn ;
Chwiszczuk, Luiza J. ;
Hynninen, Minna J. ;
Aarsland, Dag ;
Rongve, Arvid .
ALZHEIMERS RESEARCH & THERAPY, 2018, 10
[4]   The clinical phenotype of psychiatric-onset prodromal dementia with Lewy bodies: a scoping review [J].
Gunawardana, Chaminda Withanachchi ;
Matar, Elie ;
Lewis, Simon J. G. .
JOURNAL OF NEUROLOGY, 2024, 271 (01) :606-617
[5]   Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies [J].
Lai, Thuy Thi ;
Gericke, Birthe ;
Feja, Malte ;
Conoscenti, Michael ;
Zelikowsky, Moriel ;
Richter, Franziska .
NPJ PARKINSONS DISEASE, 2023, 9 (01)
[6]   Alexithymia in Neurological Disease: A Review [J].
Ricciardi, Lucia ;
Demartini, Benedetta ;
Fotopoulou, Aikaterini ;
Edwards, Mark J. .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2015, 27 (03) :179-187
[7]   MIBG Myocardial Scintigraphy Identifies Premotor PD/DLB During a Negative DAT Scan Period: Second Report [J].
Sakakibara, Ryuji ;
Tateno, Fuyuki ;
Aiba, Yosuke ;
Ogata, Tsuyoshi ;
Kishi, Masahiko ;
Terada, Hitoshi ;
Inaoka, Tsutomu ;
Nakatsuka, Tomoya ;
Matsuoka, Katsuyoshi .
MOVEMENT DISORDERS CLINICAL PRACTICE, 2019, 6 (01) :46-50
[8]  
Shin Dong Hoon, 2006, J Clin Neurol, V2, P51, DOI 10.3988/jcn.2006.2.1.51
[9]   Clinical Manifestations of Early-Onset Dementia With Lewy Bodies Compared With Late-Onset Dementia With Lewy Bodies and Early-Onset Alzheimer Disease [J].
Sim, Jingwei ;
Li, Huihua ;
Hameed, Shahul ;
Ting, Simon Kang Seng .
JAMA NEUROLOGY, 2022, 79 (07) :702-709
[10]   The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships [J].
Snowden, Julie S. ;
Thompson, Jennifer C. ;
Stopford, Cheryl L. ;
Richardson, Anna M. T. ;
Gerhard, Alex ;
Neary, David ;
Mann, David M. A. .
BRAIN, 2011, 134 :2478-2492