Relationship between histopathological findings, clinical severity and the need for surgery in patients with Crohn's disease

Introduction: Defining histological variables that make it possible to establish the activity of Crohn's disease (CD) and predict the patients who may present a higher risk of clinical complications and surgical interventions could lead to timely adjustments in medical therapy and elective surgeries that represent a lower risk of complications. The purpose of the study is to determine the relation between the histopathological findings using the Naini and Cortina (N&C) score, the clinical severity, and the indication for surgery in a group of patients with CD. Materials and methods: Descriptive, retrospective, cross-sectional study of 44 patients diagnosed with CD, treated at the San Vicente Fundaci & oacute;n University Hospital in Medell & iacute;n, Colombia, between 2010 and 2022. Results: Of the 44 patients, 36 ileum samples and 34 colon samples were obtained. Of the patients with inflammatory behavior, 87.5% did not have surgical intervention (P P = .022), a value that remained significant in the ileum subgroup (P P = .0058). 91.3% of the patients with ileal involvement did not develop perianal disease (P P = .01). Granulomas only occurred in two patients with a colon sample (5.8%). In the histological score of N&C both in the ileum and in the colon, no statistically significant differences were obtained in relation to the surgical outcome (P P = .34 and P = .054, respectively). Conclusion: The histological index of N&C was not a predictor in Crohn's disease (CD) related to the surgical outcome. (c) 2023 Elsevier Espana, a, S.L.U. All rights reserved.