Neuro-Ophthalmic Dengue Infection: A Case Report with a Multiple Body Site Sampling Strategy and Review of Laboratory Data

被引：0

作者：

Butel-Simoes, Grace I. ^{[1
]}

Bajaj, Nupur ^{[2
]}

Asad, Sultan ^{[1
]}

Moselen, Jean ^{[1
]}

Orlando, Nicole ^{[1
]}

Steinig, Eike ^{[1
,3
]}

Tran, Thomas ^{[1
]}

Druce, Julian ^{[1
]}

Caly, Leon ^{[1
]}

Bishop, Emma ^{[2
]}

Harangozo, Chanad ^{[2
]}

Lim, Chuan Kok ^{[1
,3
]}

机构：

[1] Royal Melbourne Hosp, Doherty Inst Infect & Immun, Victorian Infect Dis Reference Lab, Melbourne, Vic 3000, Australia

[2] Peninsula Hlth, Dept Infect Dis, Melbourne, Vic 3199, Australia

[3] Univ Melbourne, Doherty Inst Infect & Immun, Dept Infect Dis, Melbourne, Vic 3000, Australia

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 07期

关键词：

dengue virus; mosquito-borne encephalitis; uveitis; optic neuropathy; neuropathogenic virus; ASSAY;

D O I：

10.3390/v16070998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue neurological disease is an uncommon yet severe complication of dengue infection. It can manifest as encephalitis, encephalopathy, neuro-ophthalmic complications, or neuromuscular disorders. Severe infection can result in viral shedding across multiple body sites. We describe a case of severe neuro-ophthalmic dengue infection in an otherwise healthy returned traveller, presenting with prolonged multiple-body-site viral detections by PCR. The dengue virus (DENV) dynamics and serological response support a direct DENV neuropathogenicity. A retrospective review of the laboratory data at the Victorian Infectious Diseases Reference Laboratory (VIDRL) suggests that blood is the most frequent sample type with DENV detection (92% of all DENV-positive samples). Genotype variation is seen across different sample types. The similarity of CSF and nasopharyngeal DENV subtypes (genotype 1 and 3) suggests a possible correlation between nasopharyngeal replication and neurological complications. The case presented highlights the direct neuropathogenicity of DENV early in the course of infection, and a potential correlation between nasopharyngeal replication and neurological disease.

引用

页数：6