Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis

被引：1

作者：

Weinbergerova, Barbora ^{[1
,2
]}

Mayer, Jiri ^{[1
,2
]}

Kabut, Tomas ^{[1
,2
]}

Sperr, Wolfgang R. ^{[3
,4
]}

Stevkova, Jana ^{[5
]}

Jonasova, Anna ^{[6
]}

Cernan, Martin ^{[7
,8
]}

Herndlhofer, Susanne ^{[3
]}

Oravcova, Iveta ^{[9
,10
]}

Sramek, Jiri ^{[11
]}

Novak, Jan ^{[12
,13
]}

Stepanova, Radka ^{[14
]}

Szotkowski, Tomas ^{[7
,8
]}

Drgona, Lubos ^{[9
,10
]}

Zak, Pavel ^{[5
]}

Valent, Peter ^{[3
,4
]}

机构：

[1] Masaryk Univ, Dept Internal Med Hematol & Oncol, Jihlavska 20, Brno 62500, Czech Republic

[2] Univ Hosp Brno, Jihlavska 20, Brno 62500, Czech Republic

[3] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[4] Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria

[5] Univ Hosp Hradec Kralove, Dept Internal Med Hematol 4, Hradec Kralove, Czech Republic

[6] Charles Univ Prague, Gen Hosp, Med Dept, Hematol, Prague, Czech Republic

[7] Palacky Univ Olomouc, Fac Med & Dent, Dept Hemato Oncol, Olomouc, Czech Republic

[8] Univ Hosp Olomouc, Olomouc, Czech Republic

[9] Comenius Univ, Dept Oncohematol, Bratislava, Slovakia

[10] Natl Canc Inst, Bratislava, Slovakia

[11] Univ Hosp Plzen, Dept Haematol & Oncol, Plzen, Czech Republic

[12] Charles Univ Prague, Fac Med 3, Dept Haematol, Prague, Czech Republic

[13] Univ Hosp Kralovske Vinohrady, Prague, Czech Republic

[14] Masaryk Univ, Fac Med, Ctr Excellence CREAT, Brno, Czech Republic

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 05期

关键词：

acute myeloid leukaemia; antifungal prophylaxis; fungal infection; venetoclax and azacitidine;

D O I：

10.1111/bjh.19670

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our observational study analysed fungal infection frequency within cohorts with versus without antifungal prophylaxis (AFP) among newly diagnosed first-line venetoclax and azacitidine (VEN + AZA)-treated acute myeloid leukaemias in Czech, Austrian and Slovak haematology centres. Among 186 patients, 85 (46%) received antifungal prophylaxis, while 101 (54%) received no prophylaxis. Fungal infections occurred in 1/85 patients with prophylaxis (1%) and 5/101 patients without prophylaxis (5%) (p = 0.222). No significant difference was recorded between cohorts with and without AFP in terms of death rate (p = 0.296) and overall survival (p = 0.844). In conclusion, most infections were not severe, developing during the first treatment-cycle and did not affect patients' overall outcome.

引用

页码：1746 / 1750

页数：5

共 12 条

[11] Stemler J, 2022, LANCET HAEMATOL, V9, pE361, DOI 10.1016/S2352-3026(22)00073-4
[12] Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells
Teh, Charis E.
Peng, Hongke
Luo, Meng-Xiao
Tan, Tania
Trussart, Marie
Howson, Lauren J.
Chua, Chong Chyn
Muttiah, Christine
Brown, Fiona
Ritchie, Matthew E.
Wei, Andrew H.
Roberts, Andrew W.
Bryant, Vanessa L.
Anderson, Mary Ann
Lindeman, Geoffrey J.
Huang, David C. S.
Thijssen, Rachel
Gray, Daniel H. D.
[J]. BLOOD ADVANCES, 2023, 7 (12) : 2733 - 2745

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