Quinoline: A versatile bioactive scaffold and its molecular hybridization

被引：14

作者：

Bala, Ibrahim A. ^{[1
,2
]}

Al Sharif, Ohoud F. ^{[1
,3
]}

Asiri, Abdullah M. ^{[4
]}

El-Shishtawy, Reda M. ^{[1
,5
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia

[2] Bayero Univ, Dept Pure & Ind Chem, Kano, Nigeria

[3] Taif Univ, Coll Sci, Dept Chem, Taif, Saudi Arabia

[4] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21589, Saudi Arabia

[5] Natl Res Ctr, Text Res & Technol Inst, Dyeing Printing & Text Auxiliaries Dept, 33 EL Buhouth St, Dokki 12622, Giza, Egypt

来源：

RESULTS IN CHEMISTRY | 2024年 / 7卷

关键词：

Quinoline; Bioactive scaffold; Hybridization; Chemical structures; BIOLOGICAL-ACTIVITY; HYBRIDS SYNTHESIS; IN-SILICO; INHIBITOR; DESIGN; DELTA; IDENTIFICATION; ANTIBACTERIAL; DERIVATIVES;

D O I：

10.1016/j.rechem.2024.101529

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quinolines have become essential to many drugs, including broad-spectrum antibiotics, antivirus, antitubercular, and antimalarial agents. Owing to their importance in medicinal and pharmaceutic industries, several studies have been conducted to synthesize new and novel quinoline derivatives and their hybrid compounds with potent biological applications. In this review, we report the recent research involved in the search for biologically active molecules containing quinoline moiety, including their hybrids. The review provides information on advancements in the last ten years in the chemistry of hybrids and derivatives of quinolines. Also, the medicinal impact of some potent patents based on quinoline derivatives is discussed.

引用

页数：46

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