Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case-Control Study

被引:7
作者
Yu, Tzu-Ning [1 ,2 ]
Lee, Tsung-Hsien [1 ,2 ,3 ]
Lee, Maw-Sheng [1 ,2 ,3 ]
Chen, Yi-Chun [2 ]
Chen, Chung-, I [2 ]
Cheng, En-Hui [2 ]
Lin, Pin-Yao [2 ]
Huang, Chun-Chia [2 ]
Lee, Chun-, I [1 ,2 ,3 ]
机构
[1] Chung Shan Med Univ, Inst Med, Taichung 402, Taiwan
[2] Lee Womens Hosp, Div Infertil, Taichung 406, Taiwan
[3] Chung Shan Med Univ Hosp, Dept Obstet & Gynecol, Taichung 402, Taiwan
关键词
autologous platelet-rich plasma; intrauterine infusion; hysteroscopic injection; thin endometrium; frozen-thaw embryo transfer; THAWED EMBRYO-TRANSFER; STEM-CELLS; PREGNANCY; THICKNESS; IVF; IMPLANTATION; INFERTILITY; OUTCOMES; FRESH;
D O I
10.3390/jcm13102838
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To evaluate the effect of intrauterine infusion and hysteroscopic injection of autologous platelet-rich plasma (PRP) in patients with a persistent thin endometrium (EM) undergoing euploid frozen embryo transfer (EFET) cycles. Methods: This prospective case-control study enrolled 116 infertile women with thin EM (<7 mm) who underwent hormone replacement therapy (HRT) for EFET. These women had experienced at least one previous unsuccessful EFET cycle, which either resulted in the cancellation of the cycle or failure of pregnancy. A total of 55 women received an intrauterine infusion of PRP before FET, 38 received a hysteroscopic injection of PRP, and 23 received standard HRT treatment without PRP (control group). Only euploid embryos were transferred in these cycles. The primary outcomes were the implantation rate (IR) and clinical pregnancy rate (CPR) after EFET. Results: After receiving intrauterine infusion and hysteroscopic injection of PRP, 78.2% and 55.3% of patients, respectively, showed an EM thickness exceeding 7 mm, followed by embryo transfer. The hysteroscopic injection group demonstrated significantly higher IR (52%), a higher trend of CPR (52%), and a higher live birth rate (38%) than the control group (18%, 22%, and 4%). Conclusions: Intrauterine infusion and hysteroscopic injection of autologous PRP may be effective methods to increase EM thickness in HRT cycles. According to our results, both methods could increase EM thickness, while hysteroscopic injection appeared to provide more significant assistance in increasing IR, CPR, and live birth rate after EFET in patients with persistent thin EM.
引用
收藏
页数:12
相关论文
共 44 条
[1]  
Adibi A, 2015, J RES MED SCI, V20, P879, DOI [10.4103/1735-1995.170622, 10.4103/1735-1995.170622]
[2]   Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study [J].
Agarwal, Meenu ;
Mettler, Liselotte ;
Jain, Smita ;
Meshram, Sandhya ;
Gunther, Veronika ;
Alkatout, Ibrahim .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (09) :1-12
[3]   PLATELETS FOR ENDOMETRIAL REGENERATION: A NOVEL APPROACH. [J].
Aghajanova, L. ;
Houshdaran, S. ;
Balayan, S. ;
Irwin, J. ;
Huddleston, H. ;
Giudice, L. .
FERTILITY AND STERILITY, 2016, 106 (03) :E82-E82
[4]   The spatio-temporal dynamics of mitochondrial membrane potential during oocyte maturation [J].
AL-Zubaidi, Usama ;
Liu, Jun ;
Cinar, Ozgur ;
Robker, Rebecca L. ;
Adhikari, Deepak ;
Carroll, John .
MOLECULAR HUMAN REPRODUCTION, 2019, 25 (11) :695-705
[5]   Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors [J].
Amable, Paola Romina ;
Vieira Carias, Rosana Bizon ;
Telles Teixeira, Marcus Vinicius ;
Pacheco, Italo da Cruz ;
Farias Correa do Amaral, Ronaldo Jose ;
Granjeiro, Jose Mauro ;
Borojevic, Radovan .
STEM CELL RESEARCH & THERAPY, 2013, 4
[6]   Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome [J].
Cervello, Irene ;
Gil-Sanchis, Claudia ;
Santamaria, Xavier ;
Cabanillas, Sergio ;
Diaz, Ana ;
Faus, Amparo ;
Pellicer, Antonio ;
Simon, Carlos .
FERTILITY AND STERILITY, 2015, 104 (06) :1552-+
[7]   Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium [J].
Chang, Yajie ;
Li, Jingjie ;
Wei, Li-na ;
Pang, Jiahui ;
Chen, Jianhui ;
Liang, Xiaoyan .
MEDICINE, 2019, 98 (03)
[8]  
Chang YJ, 2015, INT J CLIN EXP MED, V8, P1286
[9]   Optimal timing of blastocyst vitrification after trophectoderm biopsy for preimplantation genetic screening [J].
Chen, Hsiu-Hui ;
Huang, Chun-Chia ;
Cheng, En-Hui ;
Lee, Tsung-Hsien ;
Chien, Lee-Feng ;
Lee, Maw-Sheng .
PLOS ONE, 2017, 12 (10)
[10]   Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies [J].
de Miguel-Gomez, Lucia ;
Lopez-Martinez, Sara ;
Campo, Hannes ;
Frances-Herrero, Emilio ;
Faus, Amparo ;
Diaz, Ana ;
Pellicer, Antonio ;
Dominguez, Francisco ;
Cervello, Irene .
FERTILITY AND STERILITY, 2021, 115 (02) :490-500