Nanomaterials-incorporated polymeric microneedles for wound healing applications

被引：7

作者：

Duan, Wei ^{[1
,2
]}

Xu, Keying ^{[1
]}

Huang, Sheng ^{[1
]}

Gao, Yue ^{[1
]}

Guo, Yong ^{[1
,2
]}

Shen, Qiying ^{[1
,2
]}

Wei, Qiaolin ^{[1
,2
,3
]}

Zheng, Wei ^{[1
,2
]}

Hu, Quan ^{[1
,2
]}

Shen, Jia-Wei ^{[1
,2
]}

机构：

[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Peoples R China

[2] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejiang, Key Lab Elemene Class Anticanc Chinese Med, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou 311121, Peoples R China

[3] Zhejiang Univ, State Key Lab Silicon Mat, Hangzhou 310027, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2024年 / 659卷

基金：

中国国家自然科学基金;

关键词：

Wound healing; Microneedle; Polymer; Transdermal delivery; Nanomaterials; HA; MeHA; PVP; PVA; cellulose; starch; SF; CS; GelMA; DRUG-DELIVERY; 2-DIMENSIONAL NANOMATERIALS; BIOMEDICAL APPLICATIONS; GELATIN NANOPARTICLES; TRANSDERMAL DELIVERY; SILK FIBROIN; HYDROGELS; ARRAYS; DRESSINGS;

D O I：

10.1016/j.ijpharm.2024.124247

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is a growing and urgent need for developing novel biomaterials and therapeutic approaches for efficient wound healing. Microneedles (MNs), which can penetrate necrotic tissues and biofilm barriers at the wound and deliver active ingredients to the deeper layers in a minimally invasive and painless manner, have stimulated the interests of many researchers in the wound-healing filed. Among various materials, polymeric MNs have received widespread attention due to their abundant material sources, simple and inexpensive manufacturing methods, excellent biocompatibility and adjustable mechanical strength. Meanwhile, due to the unique properties of nanomaterials, the incorporation of nanomaterials can further extend the application range of polymeric MNs to facilitate on-demand drug release and activate specific therapeutic effects in combination with other therapies. In this review, we firstly introduce the current status and challenges of wound healing, and then outline the advantages and classification of MNs. Next, we focus on the manufacturing methods of polymeric MNs and the different raw materials used for their production. Furthermore, we give a summary of polymeric MNs incorporated with several common nanomaterials for chronic wounds healing. Finally, we discuss the several challenges and future prospects of transdermal drug delivery systems using nanomaterials-based polymeric MNs in wound treatment application.

引用

页数：20