Effect of bisphosphonate and denosumab treatment on TBS in Japanese breast cancer patients with AIBL

被引：0

作者：

Onuma, Emi ^{[1
]}

Saito, Shin ^{[1
]}

Tsuburai, Taku ^{[1
]}

Yoshikata, Hiromi ^{[1
]}

Adachi, Shoko ^{[2
]}

Yamamoto, Shinya ^{[2
]}

Narui, Kazutaka ^{[2
]}

Hayama, Tomonari ^{[1
,3
]}

Murase, Mariko ^{[3
]}

Mizushima, Taichi ^{[4
]}

Miyagi, Etsuko ^{[4
]}

Sakakibara, Hideya ^{[1
]}

Asano, Ryoko ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Gynecol, Med Ctr, 4-57 Urafunecho,Minami Ku, Yokohama, Kanagawa 2320024, Japan

[2] Yokohama City Univ, Dept Breast Surg, Med Ctr, 4-57 Urafunecho,Minami Ku, Yokohama, Kanagawa 2320024, Japan

[3] Yokohama City Univ, Reprod Ctr, Med Ctr, 4-57 Urafunecho,Minami Ku, Yokohama, Kanagawa 2320024, Japan

[4] Yokohama City Univ Med, Dept Obstet & Gynecol, 3-9 Fukuura,Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

JOURNAL OF BONE AND MINERAL METABOLISM | 2024年 / 42卷 / 06期

关键词：

Breast cancer; Aromatase inhibitor; Bisphosphonates; Denosumab; Trabecular bone score; TRABECULAR BONE SCORE; AROMATASE-INHIBITORS; POSTMENOPAUSAL WOMEN; RISEDRONATE; ANASTROZOLE; PREVENTION; DXA; MICROARCHITECTURE; OSTEOPOROSIS; TAMOXIFEN;

D O I：

10.1007/s00774-024-01542-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IntroductionBisphosphonates and denosumab increase bone mineral density (BMD) for osteoporosis treatment in patients with aromatase inhibitor-associated bone loss (AIBL). This study aimed to directly compare bisphosphonates with denosumab in treating patients with AIBL and to determine the effect of denosumab on the trabecular bone score (TBS).Materials and methodsThirty-nine patients with AIBL receiving osteoporosis treatment (21 in the bisphosphonates group and 18 in the denosumab group) were retrospectively evaluated for changes in lumbar spine and femoral BMD, lumbar spine bone quality (assessed by TBS), and blood bone metabolic markers. The Mann-Whitney and Wilcoxon tests were used for statistical evaluation.ResultsAfter 24 months of treatment, the lumbar spine BMD change rate was 5.82 +/- 1.10% with bisphosphonates and 10.49 +/- 1.20% with denosumab, with the change rate of denosumab significantly increasing over that of bisphosphonates. The change rate in femoral BMD was 2.69 +/- 1.16% with bisphosphonates and 2.95 +/- 1.26% with denosumab, with no significant difference between the two groups. The rate of decrease in tartrate-resistant acid phosphatase isoform 5b was significantly higher in the denosumab group. The change rate in TBS at 24 months of treatment was 0.53 +/- 1.26% in the bisphosphonates group and 1.08 +/- 1.33% in the denosumab group, with no significant difference between the two groups. After 24 months, TBS remained stable.ConclusionBoth bisphosphonates and denosumab may increase BMD, improve bone metabolism, and inhibit bone quality loss in patients with AIBL.

引用

页码：699 / 709

页数：11

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