Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer's disease

被引:2
作者
Knudtzon, Stephanie Lindgard [1 ,2 ]
Nordengen, Kaja [3 ,4 ]
Grontvedt, Goril Rolfseng [5 ,6 ]
Jarholm, Jonas [3 ,4 ]
Eliassen, Ingvild Vollo [3 ,7 ]
Selnes, Per [3 ]
Palhaugen, Lene [3 ,4 ]
Espenes, Jacob [1 ,2 ]
Gisladottir, Berglind [3 ,8 ,9 ]
Waterloo, Knut [1 ,2 ]
Fladby, Tormod [3 ,4 ]
Kirsebom, Bjorn-Eivind [1 ,2 ]
机构
[1] Univ Hosp North Norway, Dept Neurol, N-9038 Tromso, Norway
[2] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Psychol, Tromso, Norway
[3] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
[4] Univ Oslo, Inst Clin Med, Oslo, Norway
[5] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway
[6] Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway
[7] Univ Oslo, Dept Psychol, Oslo, Norway
[8] Akershus Univ Hosp, Med Div, Clin Mol Biol EpiGen, Oslo, Norway
[9] Univ Oslo, Oslo, Norway
关键词
Alzheimer's disease; aging; neurofilament light chain; normative reference data; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID TAU; BIOMARKERS; DEMENTIA; PROGRESSION; PATHOLOGY; PROTEINS; MARKERS; PREDICT; IMPACT;
D O I
10.1016/j.neurobiolaging.2024.05.016
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Cerebrospinal fluid total -tau (t -tau) and neurofilament light chain (NfL) are biomarkers of neurodegeneration and are increased in Alzheimer's disease (AD). In order to adjust for age -related increases in t -tau and NfL, crosssectional age -adjusted norms were developed based on amyloid negative cognitively normal (CN) adults aged 41-78 years (CN, n = 137). The age -adjusted norms for t -tau and NfL did not improve receiver operating curve based diagnostic accuracies in individuals with mild cognitive impairment (MCI) due to AD (AD -MCI, n = 144). Furthermore, while NfL was correlated with higher age in AD -MCI, no significant correlation was found for t -tau. The cox proportional hazard models, applied in 429 participants with baseline t -tau and NfL, showed higher hazard ratio of progression to MCI or dementia without age -adjustments (HR = 3.39 for t -tau and HR = 3.17 for NfL), as compared to using our norms (HR = 2.29 for t -tau and HR = 1.89 for NfL). Our results indicate that utilizing normative reference data could obscure significant age -related increases in these markers associated with neurodegeneration and AD leading to a potential loss of overall diagnostic accuracy.
引用
收藏
页码:74 / 84
页数:11
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