Detection of measles vaccine virus and measles-specific immunoglobulin M in children vaccinated against measles-mumps-rubella during measles outbreak

被引：2
作者：
Seo, Euri [1 ,2 ,6 ]
Chang, Yun-Jung [1 ]
Chung, Jae Woo [1 ,3 ]
Chung, Yoon-Seok [4 ]
Park, Seong Yeon [1 ,5 ]
机构：
[1] Dongguk Univ, Ilsan Hosp, Coll Med, Dept Infect Control, Goyang, South Korea
[2] Ilsan Hosp, Dongguk Univ, Dept Pediat, Dept Dermatol,Coll Med, Goyang, South Korea
[3] Ilsan Hosp, Dongguk Univ, Dept Lab Med, Coll Med, Goyang, South Korea
[4] Korea Dis Control & Prevent Agcy, Bur Infect Dis Diag Control, Div High Risk Pathogens, Cheongju, South Korea
[5] Dongguk Univ, Ilsan Hosp, Dept Infect Dis, Dept Pediat, Dongguk ro 27, Goyang Si 10326, Gyeonggi Do, South Korea
[6] Korea virus Res Inst, Ctr Viral Immunol, Institue Basic Sci, Daejeon, South Korea
来源：
VACCINE: X | 2024年 / 18卷
基金：
新加坡国家研究基金会;
关键词：
Detection; Measles vaccine virus; Immunoglobulin M; Measles vaccine; Children; PARVOVIRUS B19; IGM; TRANSMISSION; ANTIBODIES; KOREA;
D O I：
10.1016/j.jvacx.2024.100491
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Information regarding the detection perioid of measles vaccine virus (MeVV) RNA in human nasopharyngeal samples and measles -specific antibodies following measles -mumps -rubella (MMR) vaccination is limited. During contact tracing for a measles outbreak at a hospital in Republic of Korea, 4 out of 206 children vaccinated with MMR underwent real-time RT-PCR assay for measles and measles -specific antibodies test. Measles virus RNA was detected in 2 children, all of which was vaccine virus strain RNA (genotype A). In a healthy 27 -month -old boy, MeVV RNA was detected 448 days after MMR vaccination. Measles -specific IgM was positive 1097 days following vaccination in a 4 -year -old girl. MeVV RNA and measles -specific IgM were detected for a considerable period following primary MMR vaccination. Physicians should exercise caution when interpreting positive RTPCR results for MeVV or measles -specific IgM from a child with measles -associated symptoms who has been recently vaccinated against measles.
引用
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页数：4
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