Integrating frontiers: a holistic, quantum and evolutionary approach to conquering cancer through systems biology and multidisciplinary synergy

被引：1

作者：

Casotti, Matheus Correia ^{[1
]}

Meira, Debora Dummer ^{[1
]}

Zetum, Alexia Stefani Siqueira ^{[1
]}

Campanharo, Camilly Victoria ^{[1
]}

da Silva, Danielle Ribeiro Campos ^{[1
]}

Giacinti, Giulia Maria ^{[1
]}

da Silva, Iris Moreira ^{[1
]}

Moura, Joao Augusto Diniz ^{[2
]}

Barbosa, Karen Ruth Michio ^{[1
]}

Altoe, Lorena Souza Castro ^{[1
]}

Mauricio, Lorena Souza Rittberg ^{[2
]}

Goes, Luiza Santa Brigida de Barros ^{[3
]}

Alves, Lyvia Neves Rebello ^{[1
]}

Linhares, Sarah Sophia Guedes ^{[4
]}

Ventorim, Vinicius do Prado ^{[1
]}

Guaitolini, Yasmin Moreto ^{[1
]}

dos Santos, Eldamaria de Vargas Wolfgramm ^{[1
]}

Errera, Flavia Imbroisi Valle ^{[1
]}

Groisman, Sonia ^{[5
]}

de Carvalho, Elizeu Fagundes ^{[5
]}

de Paula, Flavia ^{[1
]}

de Sousa, Marcelo Victor Pires ^{[6
]}

Pierre Basilio Almeida, Fechine ^{[7
]}

Louro, Iuri Drumond ^{[1
]}

机构：

[1] Univ Fed Espirito St UFES, Nucleo Genet Humana & Mol, Vitoria, ES, Brazil

[2] Univ Fed Espirito Santo UFES, Lab Oncol Clin & Expt, Vitoria, ES, Brazil

[3] Univ Sao Paulo, Grp Bioanalit Microfabricacao & Separacoes BioMicS, Sao Carlos, SP, Brazil

[4] Univ Fed Rio Grande Norte UFRN, Lab Estudos Neuroquim, Natal, RN, Brazil

[5] Univ Estado Rio de Janeiro UERJ, Inst Biol Roberto Alcantara Gomes IBRAG, Rio De Janeiro, RJ, Brazil

[6] Tergos Pesquisa & Ensino SA, Bright Photomed, Sao Paulo, SP, Brazil

[7] Fed Univ Ceara UFC, Dept Analyt Chem & Phys Chem, Grp Chem Adv Mat GQMat, Fortaleza, CE, Brazil

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

neoplasms; carcinogenesis; biological evolution; chaos and quantum theory; dynamics; translational science; PRECISION-ONCOLOGY; ORIGIN; CELLS; CHAOS; HETEROGENEITY; ADAPTATION; RESILIENCE; POLYPLOIDY; PRINCIPLES; GENOMICS;

D O I：

10.3389/fonc.2024.1419599

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer therapy is facing increasingly significant challenges, marked by a wide range of techniques and research efforts centered around somatic mutations, precision oncology, and the vast amount of big data. Despite this abundance of information, the quest to cure cancer often seems more elusive, with the "war on cancer" yet to deliver a definitive victory. A particularly pressing issue is the development of tumor treatment resistance, highlighting the urgent need for innovative approaches. Evolutionary, Quantum Biology and System Biology offer a promising framework for advancing experimental cancer research. By integrating theoretical studies, translational methods, and flexible multidisciplinary clinical research, there's potential to enhance current treatment strategies and improve outcomes for cancer patients. Establishing stronger links between evolutionary, quantum, entropy and chaos principles and oncology could lead to more effective treatments that leverage an understanding of the tumor's evolutionary dynamics, paving the way for novel methods to control and mitigate cancer. Achieving these objectives necessitates a commitment to multidisciplinary and interprofessional collaboration at the heart of both research and clinical endeavors in oncology. This entails dismantling silos between disciplines, encouraging open communication and data sharing, and integrating diverse viewpoints and expertise from the outset of research projects. Being receptive to new scientific discoveries and responsive to how patients react to treatments is also crucial. Such strategies are key to keeping the field of oncology at the forefront of effective cancer management, ensuring patients receive the most personalized and effective care. Ultimately, this approach aims to push the boundaries of cancer understanding, treating it as a manageable chronic condition, aiming to extend life expectancy and enhance patient quality of life.

引用

页数：17

共 2 条

[1] Computer-Aided Whole-Cell Design: Taking a Holistic Approach by Integrating Synthetic With Systems Biology
Marucci, Lucia
Barberis, Matteo
Karr, Jonathan
Ray, Oliver
Race, Paul R.
Andrade, Miguel de Souza
Grierson, Claire
Hoffmann, Stefan Andreas
Landon, Sophie
Rech, Elibio
Rees-Garbutt, Joshua
Seabrook, Richard
Shaw, William
Woods, Christopher
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8
[2] Multi-scale network targeting: A holistic systems-biology approach to cancer treatment
Paul, Doru
Komarova, Natalia L.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2021, 165 : 72 - 79

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