RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

被引：0

作者：

Xu, Lu ^{[1
,2
,4
]}

Xie, Zhi-Hao ^{[1
]}

Li, Jun ^{[3
]}

Tao, Shi ^{[1
]}

Ren, Fang-Li ^{[2
]}

Wang, Yin-Yin ^{[2
]}

Chang, Zhi-Jie ^{[2
]}

Hao, Xin-Bao ^{[1
,2
]}

机构：

[1] Hainan Med Univ, Affiliated Hosp 1, Dept Hematol, Haikou 570102, Peoples R China

[2] Tsinghua Univ, Sch Med, State Key Lab Membrane Biol, Beijing 100084, Peoples R China

[3] Heya Beijing Medbiotech Inc, Beijing 100084, Peoples R China

[4] Roswell Pk Comprehens Canc Ctr, Dept Hematol, Buffalo, NY 14263 USA

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE | 2024年 / 14卷 / 07期

基金：

海南省自然科学基金;

关键词：

RPRD1B; RNAP II; Diffuse large B-cell lymphoma; NF-kappa B; Apoptosis; PROMOTES TUMOR-GROWTH; POOR-PROGNOSIS; CANCER CELLS; CREPT; EXPRESSION; CYCLE; PROLIFERATION; TRANSCRIPTION; MIGRATION;

D O I：

10.4103/apjtb.apjtb_172_24

中图分类号：

R188.11 [热带医学];

学科分类号：

摘要：

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma (DLBCL) and its potential as a therapeutic target.Methods:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival analysis. In vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and apoptosis.Results:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor prognosis. In vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-kappa B signaling pathway.Conclusions:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular proliferation. Targeting RPRD1B may offer a novel therapeutic strategy for DLBCL, suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

引用

页码：307 / 317

页数：11

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[31] Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma [J].

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