Comparison of statins effects on serum concentrations of leptin and adiponectin

Studies linking the statins effect over adipocytokines levels have reported controversies; therefore, it is necessary to contribute to elucidate the relationship between them. The objective of this study was to compare leptin and adiponectin serum concentrations, according to the statin regimen. Tha present is an observational, cross-sectional, and relational -level study. Data of clinical history for 76 participants were obtained, and leptin and adiponectin were quantified by using ELISA sandwich technique. The relational analysis was performed using U -Mann -Whitney and H-Kruskal-Wallis. Serum leptin concentrations were homogeneous and independent of the statin regimen; on the contrary, those of adiponectin were lower in those who consumed 40 mg / day of atorvastatin. Atorvastatin at 40 mg / day is associated with plasma adiponectin concentrations lower than adiponectinemia in participants who were treated with other statin regimens. It is important for the scientific community to research on these biomarkers in order to elucidate relationships that will allow a more accurate prediction of the impact, especially atorvastatin at intermediate and high doses, as a drug with greater benefits against cardiovascular events and metabolic syndrom.