Electrochemical Nickel-Catalyzed Cross-Electrophile Coupling of Alkenyl Triflates with α-Chloroamides

被引：1

作者：

Zhang, Xi ^{[1
]}

Ye, Zenghui ^{[1
]}

Li, Yicai ^{[1
]}

Zhao, Ziqiang ^{[1
]}

Ma, Weiyuan ^{[1
]}

Zhang, Fengzhi ^{[1
]}

机构：

[1] Hangzhou Med Coll, Sch Pharm, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 30期

基金：

中国国家自然科学基金;

关键词：

ALKYL-HALIDES;

D O I：

10.1021/acs.orglett.4c02072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cross-electrophile coupling reactions of different electrophiles have been extensively studied but mainly limited to bromides and iodides. Here, we report an electrochemically induced nickel-catalyzed cross-electrophile coupling strategy between alkenyl triflates and alpha-chloroamides in an undivided cell under mild reaction conditions, affording the alpha-functionalized amide derivatives in good to excellent yields with broad substrate scopes and good functional group tolerance. The control experiments were conducted, and a plausible mechanism was proposed.

引用

页码：6364 / 6369

页数：6

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