Breast Relapse of Pediatric B-Cell Acute Lymphoblastic Leukemia After CAR-T Therapy Detected by 18F-FDG PET/CT

被引：1

作者：

Perrone, Elisabetta ^{[1
,2
]}

Taralli, Silvia ^{[1
]}

Pagliara, Daria ^{[3
]}

Larocca, Luigi Maria ^{[4
]}

Vinti, Luciana ^{[3
]}

Leccisotti, Lucia ^{[1
,2
]}

机构：

[1] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Diagnost Imaging Radiat Oncol & Hematol, Nucl Med Unit, Largo Francesco Vito 1, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Radiol & Hematol Sci, Sect Nucl Med, Rome, Italy

[3] Bambino Gesu Pediat Hosp, Dept Paediat Haematol Oncol Cell & Gene Therapy, IRCCS, Rome, Italy

[4] Int Univ Hlth & Med Sci Rome, Unicamillus, Rome, Italy

来源：

ANTICANCER RESEARCH | 2024年 / 44卷 / 05期

关键词：

18; F-FDG; PET/CT; chimeric antigen receptor T cell therapy; B-cell acute lymphoblastic leukemia; breast; pediatric; INFILTRATION;

D O I：

10.21873/anticanres.17032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

(B-ALL) is the most common childhood malignancy. Medullary and extramedullary disease relapse is a wellknown occurrence in B-ALL pediatric patients treated with standard chemo-immunotherapy and, more recently, with chimeric antigen receptor (CAR)-T cell therapy. 18FFluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) emerges as a sensitive imaging tool for detecting disease relapse at extra-medullary sites, with only limited literature evidence in the CAR-T therapy setting. Case Report: In a 12-year-old female treated with CAR-T therapy for B-ALL relapse, 18F-FDG PET/CT scan performed for surveillance, after disease remission, detected a solitary and clinically occult relapse in the breast parenchyma that was histologically confirmed. Conclusion: At our knowledge, this is the first report about a pediatric B-ALL patient with a solitary and occult breast relapse after CAR-T therapy, early discovered by 18F-FDG PET/CT during disease monitoring.

引用

页码：2243 / 2245

页数：3