Stem Cells in Bone Tissue Engineering: Progress, Promises and Challenges

被引：7

作者：

Augustine, Robin ^{[1
,2
]}

Gezek, Mert ^{[2
,3
]}

Nikolopoulos, Vasilios K. ^{[2
]}

Buck, Paige Lauren ^{[2
,3
]}

Bostanci, Nazli Seray ^{[2
,3
]}

Camci-Unal, Gulden ^{[2
,4
]}

机构：

[1] Stanford Univ, Dept Radiol, Stanford Med, Palo Alto, CA 94304 USA

[2] Univ Massachusetts, Dept Chem Engn, Lowell, MA 01854 USA

[3] Univ Massachusetts, Biomed Engn & Biotechnol Grad Program, Lowell, MA 01854 USA

[4] Univ Massachusetts, Dept Surg, Med Sch, Worcester, MA 01605 USA

来源：

STEM CELL REVIEWS AND REPORTS | 2024年 / 20卷 / 07期

关键词：

Bone defects; Osteogenesis; Bone tissue engineering; Hydrogels; iPSCs; Mesenchymal stem cells; DECELLULARIZED EXTRACELLULAR-MATRIX; OXYGEN GENERATING SCAFFOLDS; SELF-ASSEMBLING PEPTIDES; OSTEOGENIC DIFFERENTIATION; CALCIUM-PHOSPHATE; IN-VIVO; OSTEOBLAST DIFFERENTIATION; AMNIOTIC-FLUID; REGENERATIVE MEDICINE; BIOLOGICAL-PROPERTIES;

D O I：

10.1007/s12015-024-10738-y

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Bone defects from accidents, congenital conditions, and age-related diseases significantly impact quality of life. Recent advancements in bone tissue engineering (TE) involve biomaterial scaffolds, patient-derived cells, and bioactive agents, enabling functional bone regeneration. Stem cells, obtained from numerous sources including umbilical cord blood, adipose tissue, bone marrow, and dental pulp, hold immense potential in bone TE. Induced pluripotent stem cells and genetically modified stem cells can also be used. Proper manipulation of physical, chemical, and biological stimulation is crucial for their proliferation, maintenance, and differentiation. Stem cells contribute to osteogenesis, osteoinduction, angiogenesis, and mineralization, essential for bone regeneration. This review provides an overview of the latest developments in stem cell-based TE for repairing and regenerating defective bones.

引用

页码：1692 / 1731

页数：40