Imbalance of SARS-CoV-2-specific CCR6+and CXCR3+CD4+T cells and IFN-γ+CD8+T cells in patients with Long-COVID

被引：1

作者：

Martinez-Fleta, Pedro ^{[1
]}

Marcos, Maria Celeste ^{[2
]}

Jimenez-Carretero, Daniel ^{[3
]}

Galvan-Roman, Jose Maria ^{[4
]}

Giron-Moreno, Rosa Maria ^{[2
]}

Calero-Garcia, Ana Adela ^{[1
]}

Arcos-Garcia, Ana ^{[2
]}

Martin-Gayo, Enrique ^{[1
,6
,7
]}

de la Fuente, Hortensia ^{[1
,5
]}

Esparcia-Pinedo, Laura ^{[1
]}

Aspa, Javier ^{[2
]}

Ancochea, Julio ^{[2
]}

Alfranca, Arantzazu ^{[1
,5
,6
]}

Sanchez-Madrid, Francisco ^{[1
,5
,6
]}

机构：

[1] Hosp Univ La Princesa, Hosp Univ La Princesa IIS Princesa, Inst Invest Sanitaria, Dept Immunol, Madrid, Spain

[2] Hosp Univ La Princesa, Hosp Univ La Princesa IIS Princesa, Inst Invest Sanitaria, Dept Pneumol, Madrid, Spain

[3] Ctr Nacl Invest Cardiovasc CNIC, Bioinformat Unit, Madrid, Spain

[4] Hosp Univ La Princesa, Hosp Univ La Princesa IIS Princesa, Inst Invest Sanitaria, Dept Internal Med, Madrid, Spain

[5] CIBER Cardiovasc CIBERCV, Madrid, Spain

[6] Univ Autonoma Madrid UAM, Dept Med, Madrid, Spain

[7] Inst Salud Carlos III, CIBER Infect Dis CIBERINFECC, Madrid, Spain

来源：

CLINICAL IMMUNOLOGY | 2024年 / 264卷

关键词：

Long-COVID; COVID-19; Chemokine receptors; IFN-gamma; T cells; TH17; CELLS; IMMUNITY;

D O I：

10.1016/j.clim.2024.110267

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Long-COVID (LC) is characterised by persistent symptoms for at least 3 months after acute infection. A dysregulation of the immune system and a persistent hyperinflammatory state may cause LC. LC patients present differences in activation and exhaustion states of innate and adaptive compartments. Different T CD4+ cell subsets can be identified by differential expression of chemokine receptors (CCR). However, changes in T cells with expression of CCRs such as CCR6 and CXCR3 and their relationship with CD8+ T cells remains unexplored in LC. Here, we performed unsupervised analysis and found CCR6+ CD4+ subpopulations enriched in COVID-19 convalescent individuals upon activation with SARS-CoV-2 peptides. SARS-CoV-2 specific CCR6+ CD4+ are decreased in LC patients, whereas CXCR3+ CCR6- and CCR4+ CCR6- CD4+ T cells are increased. LC patients showed lower IFN-gamma-secreting CD8+ T cells after stimulation with SARS-CoV-2 Spike protein. This work underscores the role of CCR6 in the pathophysiology of LC.

引用

页数：6

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