Inhibitory Effects of Soluble Dietary Fiber from Foxtail Millet on Colorectal Cancer by the Restoration of Gut Microbiota

被引：4
作者：
Zhao, Wenjing [1 ,2 ,3 ]
Ren, Aiqi [2 ]
Shan, Shuhua [1 ]
Li, Zhuoyu [1 ]
Su, Ruijun [2 ]
Yang, Ruipeng [2 ]
Zhai, Feihong [2 ]
Wu, Lihua [2 ]
Tang, Zhaohui [3 ]
Yang, Jieya [2 ]
Yue, Linzhong [2 ]
机构：
[1] Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China
[2] Taiyuan Normal Univ, Biol Sci & Technol Coll, Jinzhong 030619, Peoples R China
[3] Shanxi Acad Agr Sci, Taiyuan 030006, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2024年 / 72卷 / 21期
基金：
中国国家自然科学基金;
关键词：
colorectal cancer; foxtailmillet; solubledietary fiber; gut microbiome; AOM/DSS; INFLAMMATORY-BOWEL-DISEASE; BACTERIAL METABOLITES; CARCINOGENESIS; HEALTH; PROMOTES;
D O I：
10.1021/acs.jafc.4c00867
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Colorectal cancer (CRC) is a common malignant tumor that occurs in the colon. Gut microbiota is a complex ecosystem that plays an important role in the pathogenesis of CRC. Our previous studies showed that the soluble dietary fiber of foxtail millet (FMB-SDF) exhibited significant antitumor activity in vitro. The present study evaluated the anticancer potential of FMB-SDF in the azoxymethane (AOM)- and dextran sodium sulfate (DSS)-induced mouse CRC models. The results showed that FMB-SDF could significantly alleviate colon cancer symptoms in mice. Further, we found that FMB-SDF consumption significantly altered gut microbiota diversity and the overall structure and regulated the abundance of some microorganisms in CRC mice. Meanwhile, KEGG pathway enrichment showed that FMB-SDF can also alleviate the occurrence of colon cancer in mice by regulating certain cancer-related signaling pathways. In conclusion, our findings may provide a novel approach for the prevention and biotherapy of CRC.
引用
收藏
页码：12130 / 12145
页数：16
相关论文
共 48 条
[1]  
[Anonymous], 2023, COLORECTALCANCER
[2]  
Ariake Koichiro, 2000, Journal of Medical and Dental Sciences, V47, P233
[3]   Global patterns and trends in colorectal cancer incidence and mortality [J].
Arnold, Melina ;
Sierra, Monica S. ;
Laversanne, Mathieu ;
Soerjomataram, Isabelle ;
Jemal, Ahmedin ;
Bray, Freddie .
GUT, 2017, 66 (04) :683-691
[4]   Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies [J].
Aune, Dagfinn ;
Chan, Doris S. M. ;
Lau, Rosa ;
Vieira, Rui ;
Greenwood, Darren C. ;
Kampman, Ellen ;
Norat, Teresa .
BMJ-BRITISH MEDICAL JOURNAL, 2011, 343 :1082
[5]   Structural elucidation, anti-inflammatory activity and intestinal barrier protection of longan pulp polysaccharide LPIIa [J].
Bai, Yajuan ;
Jia, Xuchao ;
Huang, Fei ;
Zhang, Ruifen ;
Dong, Lihong ;
Liu, Lei ;
Zhang, Mingwei .
CARBOHYDRATE POLYMERS, 2020, 246
[6]   Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis [J].
Beukema, Martin ;
Akkerman, Renate ;
Jermendi, Eva ;
Koster, Taco ;
Laskewitz, Anne ;
Kong, Chunli ;
Schols, Henk A. ;
Faas, Marijke M. ;
de Vos, Paul .
MOLECULAR NUTRITION & FOOD RESEARCH, 2021, 65 (19)
[7]   Dodecyl gallate induces apoptosis by upregulating the caspase-dependent apoptotic pathway and inhibiting the expression of anti-apoptotic Bcl-2 family proteins in human osteosarcoma cells [J].
Cheng, Chun-Hsiang ;
Cheng, Yen-Po ;
Chang, Ing-Lin ;
Chen, Hsin-Yao ;
Wu, Chia-Chieh ;
Hsieh, Chen-Pu .
MOLECULAR MEDICINE REPORTS, 2016, 13 (02) :1495-1500
[8]   Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota [J].
Gong, Yanling ;
Dong, Rong ;
Gao, Xiaomeng ;
Li, Jin ;
Jiang, Li ;
Zheng, Jiale ;
Cui, Sunliang ;
Ying, Meidan ;
Yang, Bo ;
Cao, Ji ;
He, Qiaojun .
PHARMACOLOGICAL RESEARCH, 2019, 148
[9]   Characterization of soluble dietary fiber from citrus peels (Citrus unshiu), and its antioxidant capacity and beneficial regulating effect on gut microbiota [J].
Gu, Qing ;
Gao, Xin ;
Zhou, Qingqing ;
Li, Yongquan ;
Li, Guoqiang ;
Li, Ping .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 246
[10]   Polysaccharides isolated from Nostoc commune Vaucher inhibit colitis-associated colon tumorigenesis in mice and modulate gut microbiota [J].
Guo, Min ;
Li, Zhuoyu .
FOOD & FUNCTION, 2019, 10 (10) :6873-6881
12345