Crebinostat facilitates memory formation

被引：0

作者：

Dama, Deepti ^{[1
]}

Sharma, Shiv K. ^{[1
,2
]}

机构：

[1] Natl Brain Res Ctr, Manesar 122052, Haryana, India

[2] Univ Allahabad, Ctr Behav & Cognit Sci, Prayagraj 211002, Uttar Pradesh, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2024年 / 710卷

关键词：

Acetylation; Memory; Object recognition task; alpha-tubulin; HDAC6; SYNAPTIC PLASTICITY; HISTONE ACETYLATION; CHROMATIN; TRANSCRIPTION;

D O I：

10.1016/j.bbrc.2024.149872

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein modifications importantly contribute to memory formation. Protein acetylation is a post-translational modification of proteins that regulates memory formation. Acetylation level is determined by the relative activities of acetylases and deacetylases. Crebinostat is a histone deacetylase inhibitor. Here we show that in an object recognition task, crebinostat facilitates memory formation by a weak training. Further, this compound enhances acetylation of alpha-tubulin, and reduces the level of histone deacetylase 6, an alpha-tubulin deacetylase. The results suggest that enhanced acetylation of alpha-tubulin by crebinostat contributes to its facilitatory effect on memory formation.

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页数：5

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