Compromised TGFβ signaling and DNA repair primes immune poor tumors response to immune checkpoint blockade by activating NK cells

被引:0
|
作者
Moore, Jade T.
Gkantalis, Jim
Guix, Ines
Barcellos-Hoff, Mary Helen
机构
关键词
D O I
10.1158/1538-7445.AM2024-6651
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6651
引用
收藏
页数:2
相关论文
共 50 条
  • [41] B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
    Johannes Griss
    Wolfgang Bauer
    Christine Wagner
    Martin Simon
    Minyi Chen
    Katharina Grabmeier-Pfistershammer
    Margarita Maurer-Granofszky
    Florian Roka
    Thomas Penz
    Christoph Bock
    Gao Zhang
    Meenhard Herlyn
    Katharina Glatz
    Heinz Läubli
    Kirsten D. Mertz
    Peter Petzelbauer
    Thomas Wiesner
    Markus Hartl
    Winfried F. Pickl
    Rajasekharan Somasundaram
    Peter Steinberger
    Stephan N. Wagner
    Nature Communications, 10
  • [42] B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
    Griss, Johannes
    Bauer, Wolfgang
    Wagner, Christine
    Simon, Martin
    Chen, Minyi
    Grabmeier-Pfistershammer, Katharina
    Maurer-Granofszky, Margarita
    Roka, Florian
    Penz, Thomas
    Bock, Christoph
    Zhang, Gao
    Herlyn, Meenhard
    Glatz, Katharina
    Laubli, Heinz
    Mertz, Kirsten D.
    Petzelbauer, Peter
    Wiesner, Thomas
    Hartl, Markus
    Pickl, Winfried F.
    Somasundaram, Rajasekharan
    Steinberger, Peter
    Wagner, Stephan N.
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [43] B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
    Griss, J.
    Bauer, W.
    Wagner, C.
    Simon, M.
    Chen, M.
    Grabmeier-Pfistershammer, K.
    Steinberger, P.
    Wagner, S. N.
    EXPERIMENTAL DERMATOLOGY, 2023, 32 (04) : E69 - E69
  • [44] B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
    Griss, J.
    Bauer, W.
    Wagner, C.
    Simon, M.
    Chen, M.
    Grabmeier-Pfistershammer, K.
    Steinberger, P.
    Wagner, S. N.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (09) : S297 - S297
  • [45] Combined DNA repair defects in testicular metastasis from prostate cancer sensitize to immune checkpoint blockade
    Vlachostergios, Panagiotis J.
    CURRENT UROLOGY, 2021, 15 (04) : 234 - 237
  • [46] DNA damage and repair gene panel as a biomarker of immune checkpoint inhibitor response.
    Chen, Ming Huang
    Pan, Yi-Ru
    Wu, Chiao-En
    Yeh, Yi Chen
    Hung, Yi-Ping
    Chao, Yee
    Wang, Yu-Chao
    Lin, Chien-Hsing
    Hsieh, Jason Chia-Hsun
    Yeh, Chun-Nan
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [47] Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade
    Catena, Xavier
    Contreras-Alcalde, Marta
    Juan-Larrea, Naiara
    Cerezo-Wallis, Daniela
    Calvo, Tonantzin G.
    Mucientes, Cynthia
    Olmeda, David
    Suarez, Javier
    Oterino-Sogo, Sergio
    Martinez, Lola
    Megias, Diego
    Sancho, David
    Tejedo, Cristina
    Frago, Susana
    Dudziak, Diana
    Seretis, Athanasios
    Stoitzner, Patrizia
    Soengas, Maria S.
    NATURE CANCER, 2025,
  • [48] Tissue-Resident T Cells in Clinical Response and Immune-Related Adverse Events of Immune Checkpoint Blockade
    Zhao, Ye
    Wucherpfennig, Kai W.
    CLINICAL CANCER RESEARCH, 2024, 30 (24) : 5527 - 5534
  • [49] Pathological Tumor Response Following Immune Checkpoint Blockade for Deficient Mismatch Repair Advanced Colorectal Cancer
    Ludford, Kaysia
    Cohen, Romain
    Svrcek, Magali
    Foo, Wai Chin
    Colle, Raphael
    Parc, Yann
    Thomas, Jane Varkey
    Morris, Van Karlyle
    Kopetz, Scott
    Chang, George J.
    Overman, Michael
    Andre, Thierry
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021, 113 (02): : 208 - 211
  • [50] Are DNA Repair Gene Alterations Associated With the Response to Platinum-Based Regimen and Immune Checkpoint Inhibitors in Patients With Solid Tumors?
    Chabot, Clement
    Italiano, Antoine
    Crombe, Amandine
    Soubeyran, Isabelle
    Laizet, Yech'an
    Khalifa, Emmanuel
    Cousin, Sophie
    ONCOLOGIST, 2024, : 452 - 455