Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes

被引：21
作者：
Feng, Yuhan [1 ]
Ren, Yan [1 ]
Zhang, Xia [1 ]
Yang, Songqin [1 ]
Jiao, Qian [1 ]
Li, Qiuhong [1 ]
Jiang, Wenwen [1 ]
机构：
[1] Guizhou Univ, Sch Pharmaceut Sci, Guiyang, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
关键词：
metabolites; traditional Chinese medicine; type 2 diabetes mellitus; insulin resistance; PI3K/AKT signaling pathway; HIGH-FAT DIET; HEPATIC INSULIN-RESISTANCE; PANCREATIC BETA-CELLS; GLUCOSE-UPTAKE; OXIDATIVE STRESS; LIPID-METABOLISM; SKELETAL-MUSCLE; GALLIC ACID; ASIATIC ACID; AMELIORATES HYPERGLYCEMIA;
D O I：
10.3389/fphar.2024.1373711
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Type 2 diabetes mellitus is a chronic metabolic disease characterized by insulin resistance, with high morbidity and mortality worldwide. Due to the tightly intertwined connection between the insulin resistance pathway and the PI3K/AKT signaling pathway, regulating the PI3K/AKT pathway and its associated targets is essential for hypoglycemia and the prevention of type 2 diabetes mellitus. In recent years, metabolites isolated from traditional Chinese medicine has received more attention and acceptance for its superior bioactivity, high safety, and fewer side effects. Meanwhile, numerous in vivo and in vitro studies have revealed that the metabolites present in traditional Chinese medicine possess better bioactivities in regulating the balance of glucose metabolism, ameliorating insulin resistance, and preventing type 2 diabetes mellitus via the PI3K/AKT signaling pathway. In this article, we reviewed the literature related to the metabolites of traditional Chinese medicine improving IR and possessing therapeutic potential for type 2 diabetes mellitus by targeting the PI3K/AKT signaling pathway, focusing on the hypoglycemic mechanism of the metabolites of traditional Chinese medicine in type 2 diabetes mellitus and elaborating on the significant role of the PI3K/AKT signaling pathway in type 2 diabetes mellitus. In order to provide reference for clinical prevention and treatment of type 2 diabetes mellitus.
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页数：24
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共 191 条
[1]   A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance [J].
Abubakar, Ibrahim Babangida ;
Malami, Ibrahim ;
Yahaya, Yakubu ;
Sule, Sahabi Manga .
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 224 :45-62
[2]   Role of glycogen phosphorylase in liver glycogen metabolism [J].
Agius, Loranne .
MOLECULAR ASPECTS OF MEDICINE, 2015, 46 :34-45
[3]   Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats [J].
Ahad, Amjid ;
Mujeeb, Mohd ;
Ahsan, Haseeb ;
Siddiqui, Waseem Ahmad .
BIOCHIMIE, 2014, 106 :101-110
[4]   Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities [J].
Ali, Md Yousof ;
Zaib, Sumera ;
Rahman, M. Mizanur ;
Jannat, Susoma ;
Iqbal, Jamshed ;
Park, Seong Kyu ;
Chang, Mun Seog .
BIOORGANIC CHEMISTRY, 2020, 102
[5]   Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice [J].
Alkhalidy, Hana ;
Moore, Will ;
Wang, Aihua ;
Luo, Jing ;
McMillan, Ryan P. ;
Wang, Yao ;
Zhen, Wei ;
Hulver, Matthew W. ;
Liu, Dongmin .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2018, 58 :90-101
[6]   The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions [J].
Alshehade, Salah ;
Alshawsh, Mohammed Abdullah ;
Murugaiyah, Vikneswaran ;
Asif, Muhammad ;
Alshehade, Omayma ;
Almoustafa, Hassan ;
Al Zarzour, Raghdaa Hamdan .
LIFE SCIENCES, 2022, 305
[7]   Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats [J].
Babu, Shyamaladevi ;
Krishnan, Madhan ;
Rajagopal, Ponnulakshmi ;
Periyasamy, Vijayalakshmi ;
Veeraraghavan, Vishnupriya ;
Govindan, Ramajayam ;
Jayaraman, Selvaraj .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 873
[8]   Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety [J].
Bai, Ying ;
Zhu, Ruyuan ;
Tian, Yimiao ;
Li, Rui ;
Chen, Beibei ;
Zhang, Hao ;
Xia, Bingke ;
Zhao, Dandan ;
Mo, Fangfang ;
Zhang, Dongwei ;
Gao, Sihua .
MOLECULES, 2019, 24 (18)
[9]   The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease [J].
Barone, Eugenio ;
Di Domenico, Fabio ;
Perluigi, Marzia ;
Butterfield, D. Allan .
FREE RADICAL BIOLOGY AND MEDICINE, 2021, 176 :16-33
[10]   Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics [J].
Barriocanal, Luis A. ;
Palacios, Mafalda ;
Benitez, Gilda ;
Benitez, Sussam ;
Jimenez, Jorge T. ;
Jimenez, Nora ;
Rojas, Vicenta .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2008, 51 (01) :37-41
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