Material properties of chelate-setting cement from hydroxyapatite powder with high specific surface area and their cytotoxicity

被引：0

作者：

Minamisawa, Hirogo ^{[1
]}

Suzuki, Kitaru ^{[2
]}

Kato, Shiori ^{[2
]}

Sato, Taira ^{[3
]}

Tsuru, Kanji ^{[1
]}

Kojima, Yoshiyuki ^{[4
]}

Aizawa, Mamoru ^{[2
]}

机构：

[1] Fukuoka Dent Coll, Dept Dent Engn, Sect Bioengn, 2-15-1 Tamura,Sawara Ku, Fukuoka 8140193, Japan

[2] Meiji Univ, Sch Sci & Technol, Dept Appl Chem, 1-1-1 Higashimita,Tama Ku, Kawasaki, Kanagawa 2148571, Japan

[3] Fukuoka Dent Coll, Dept Dent Engn, Sect Biomat, 2-15-1 Tamura,Sawara Ku, Fukuoka 8140193, Japan

[4] Nihon Univ, Coll Sci & Engn, Dept Mat & Appl Chem, 1-8 Kanda Surugadai,Chiyoda Ku, Tokyo 1018308, Japan

来源：

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN | 2024年 / 132卷 / 10期

关键词：

Chelate-setting cement; Hydroxyapatite; Inositol phosphate; Specific surface area; Compressive strength; Cytotoxicity; CALCIUM-PHOSPHATE CEMENTS; ADSORPTION; FABRICATION;

D O I：

10.2109/jcersj2.24067

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, improvement of material properties such as compressive strength of chelate-setting cements, which is determined by chelate-bonding between inositol phosphate (IP6) and hydroxyapatite (HAp), and cytotoxicity of cements fabricated using the osteoblastic cell line MC3T3-E1, was investigated. The use of HAp powder with a high specific fi c surface area (HApHS), synthesized by a wet process under ultrasonic irradiation, instead of the commercially available HAp powder improved the material properties of the cement. The compressive strength of the cement specimens fabricated from IP6-surface-modified fi ed HAp and HApHS powders was higher than that of cement specimens without IP6 surface modification. fi cation. Moreover, the compressive strength of the HApHS-based cement specimens increased with increasing IP6 concentration. Cytotoxicity tests using Transwell mu -permeable mu -permeable support revealed that the cement specimens had no cytotoxicity. The fabricated non-cytotoxic HApHS powders could be useful as a new raw material for preparing chelate-setting cements with improved materials properties.

引用

页码：602 / 608

页数：7

共 31 条

[1] Bioresorbable porous β-tricalcium phosphate chelate-setting cements with poly(lactic-co-glycolic acid) particles as pore-forming agent: fabrication, material properties, cytotoxicity, and in vivo evaluation [J].