In(OTf)3-Catalyzed Diastereoselective [2+3+1] Annulation of 3-Formylchromones with α-Methylstyrenes for Divergent Synthesis of Tetrahydroxanthones

被引：0
作者：
Akhtar, Muhammad Saeed [1 ]
Sim, Hyo Seon [1 ]
Aslam, Mohammad [1 ]
Rubio, Peter Yuosef M. [1 ]
Lee, Yong Rok [1 ]
机构：
[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 15期
基金：
新加坡国家研究基金会;
关键词：
Annulation; 3-Formylchromone; alpha-Methylstyrene; Diastereoselective; Tetrahydroxanthone; BIOLOGICAL EVALUATION; IN-VITRO; XANTHONES; CONSTRUCTION; DERIVATIVES; INHIBITION; DIVERSE; ENDO;
D O I：
10.1002/adsc.202400378
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An In(III)-catalyzed [2+3+1] annulation strategy is developed for the diastereoselective construction of diversely functionalized tetrahydroxanthones bearing chromone rings. This protocol is based on a three-component reaction involving various 3-formylchromones and alpha-methylstyrenes via a carbonyl-ene and formal [4+2] cycloaddition reaction. Notable features of this reaction include its wide substrate scope, high tolerance towards functional groups, atom economy, and excellent diastereoselectivity. In addition, the synthesized tetrahydroxanthones are readily transformed into 2-hydroxybenzophenone products.
引用
收藏
页码：3332 / 3337
页数：6
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