Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes

被引：1
|
作者：
Saucedo, Renata [1 ]
Ferreira-Hermosillo, Aldo [1 ]
Robledo-Clemente, Magalhi [2 ]
Diaz-Velazquez, Mary Flor [2 ]
Valencia-Ortega, Jorge [3 ]
机构：
[1] Inst Mexicano Seguro Social, Hosp Especial, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Endocrinas, Mexico City 06720, Mexico
[2] Inst Mexicano Seguro Social, Hosp Gineco Obstet 3, Ctr Med Nacl La Raza, Mexico City 02990, Mexico
[3] Univ Nacl Autonoma Mexico, Fac Quim, Unidad Invest Reprod Humana, Inst Nacl Perinatol, Mexico City 11000, Mexico
来源：
METABOLITES | 2024年 / 14卷 / 07期
关键词：
DNA methylation; epigenetics; gestational diabetes; macrosomia; birth weight; CORD BLOOD METHYLATION; EPIGENETIC REGULATION; LIPOPROTEIN-LIPASE; MELLITUS; PREGNANCY; RISK; GENE; EXPRESSION; BINDING; HYPERGLYCEMIA;
D O I：
10.3390/metabo14070361
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation of several hormones, cytokines, and growth factors related to fetal fat mass growth. One of the molecular mechanisms of GDM influencing these factors is epigenetic alterations, such as DNA methylation (DNAm). This review will examine the role of DNAm as a potential biomarker for monitoring fetal growth during pregnancy in women with GDM. This information is relevant since it may provide useful new biomarkers for the diagnosis, prognosis, and treatment of fetal growth and its later-life health consequences.
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页数：18
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