Towards broad-spectrum protection: the development and challenges of combined respiratory virus vaccines

被引：4

作者：

Wang, Yang ^{[1
,2
]}

Wei, Xiaotong ^{[1
]}

Liu, Yang ^{[1
,3
]}

Li, Shengfeng ^{[1
]}

Pan, Weiqi ^{[1
,4
]}

Dai, Jun ^{[2
,3
]}

Yang, Zifeng ^{[1
,2
,4
]}

机构：

[1] Guangzhou Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis,Guangzhou Inst Resp Hlth, Guangzhou, Peoples R China

[2] Guangzhou Natl Lab, Guangzhou, Peoples R China

[3] Guangzhou Customs Technol Ctr, Guangzhou, Peoples R China

[4] Macau Univ Sci & Technol, Fac Innovat Engn, Resp Dis AI Lab Epidem & Med Big Data Instrument A, Macau, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2024年 / 14卷

基金：

中国国家自然科学基金;

关键词：

combined vaccine; SARS-CoV-2; COVID-19; influenza virus; RSV; mRNA vaccine; subunit vaccine; viral vector vaccine; MESSENGER-RNA VACCINES; SUBUNIT VACCINES; INFLUENZA; INFECTION; SARS-COV-2; ANTIBODIES; FRONTIERS; CHILDREN; DESIGN;

D O I：

10.3389/fcimb.2024.1412478

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the post-COVID-19 era, the co-circulation of respiratory viruses, including influenza, SARS-CoV-2, and respiratory syncytial virus (RSV), continues to have significant health impacts and presents ongoing public health challenges. Vaccination remains the most effective measure for preventing viral infections. To address the concurrent circulation of these respiratory viruses, extensive efforts have been dedicated to the development of combined vaccines. These vaccines utilize a range of platforms, including mRNA-based vaccines, viral vector vaccines, and subunit vaccines, providing opportunities in addressing multiple pathogens at once. This review delves into the major advancements in the field of combined vaccine research, underscoring the strategic use of various platforms to tackle the simultaneous circulation of respiratory viruses effectively.

引用

页数：10

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