Charged particle radiotherapy for thyroid cancer. A systematic review

被引：0

作者：

Ciccone, Lucia Pia ^{[1
]}

Franzetti, Jessica ^{[1
]}

Bonora, Maria ^{[1
]}

Ronchi, Sara ^{[1
]}

Camarda, Anna Maria ^{[1
]}

Charalampopoulou, Alexandra ^{[2
,3
]}

Facoetti, Angelica ^{[2
]}

Bazani, Alessia ^{[4
]}

Magro, Giuseppe ^{[4
]}

Vischioni, Barbara ^{[1
]}

Locati, Laura Deborah ^{[5
,6
]}

Licitra, Lisa ^{[7
,8
,9
]}

Sauerwein, Wolfgang A. G. ^{[10
,11
,12
]}

Orlandi, Ester ^{[1
]}

机构：

[1] Natl Ctr Oncol Hadrontherapy CNAO, Clin Dept, I-27100 Pavia, Italy

[2] CNAO Natl Ctr Oncol Hadrontherapy, Res & Dev Dept, Radiobiol Unit, I-27100 Pavia, Italy

[3] Univ Sch Adv Studies IUSS, Hadron Acad PhD Course, I-27100 Pavia, Italy

[4] CNAO Natl Ctr Oncol Hadrontherapy, Med Phys Unit, I-27100 Pavia, Italy

[5] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy

[6] Istituti Clinici Scientif Maugeri IRCCS, Med Phys Unit, I-27100 Pavia, Italy

[7] CNAO Natl Ctr Oncol Hadrontherapy, Sci Directorate, I-27100 Pavia, Italy

[8] Fdn IRCCS Ist Nazl Tumori, Dept Head & Neck Med Oncol 3, I-20133 Milan, Italy

[9] Univ Milan, Dept Oncol & Haematooncol, I-20122 Milan, Italy

[10] Deutsch Gesell Bor Neutroneneinfangtherapie DGBNCT, Essen, Germany

[11] BNCT Global GmbH, Essen, Germany

[12] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 202卷

关键词：

Thyroid cancer; Radiotherapy; Heavy ion radiotherapy; Carbon ion radiotherapy; Proton radiation therapy; Proton therapy; Boron NEutron Capture therapy; Molecular targeted therapy; NEUTRON-CAPTURE THERAPY; NONRANDOMIZED CONTROLLED-TRIAL; EXTERNAL-BEAM RADIOTHERAPY; INDUCTION CHEMOTHERAPY; P-BOROPHENYLALANINE; CARCINOMA; PHOTON; BNCT; BIODISTRIBUTION; INTEGRATION;

D O I：

10.1016/j.critrevonc.2024.104463

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of external beam radiotherapy (EBRT) in thyroid cancer (TC) remains contentious due to limited data. Retrospective studies suggest adjuvant EBRT benefits high-risk differentiated thyroid cancer (DTC) and limitedstage anaplastic thyroid carcinoma (ATC), enhancing locoregional control and progression-free survival when combined with surgery and chemotherapy. Intensity-modulated radiotherapy (IMRT) and particle therapy (PT), including protons, carbon ions, and Boron Neutron Capture Therapy (BNCT), represent advances in TC treatment. Following PRISMA guidelines, we reviewed 471 studies from January 2002 to January 2024, selecting 14 articles (10 preclinical, 4 clinical). Preclinical research focused on BNCT in ATC mouse models, showing promising local control rates. Clinical studies explored proton, neutron, or photon radiotherapy, reporting favorable outcomes and manageable toxicity. While PT shows promise supported by biological rationale, further research is necessary to clarify its role and potential combination with systemic treatments in TC management.

引用

页数：9

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