Transformation of epidermal growth factor receptor mutated lung adenocarcinoma to small-cell carcinoma long after the cessation of tyrosine kinase inhibitor treatment: A case series and literature review

被引：1

作者：

Miyamoto, Kenya ^{[1
]}

Ogino, Hirokazu ^{[1
]}

Kakimoto, Takumi ^{[2
]}

Matsumura, Yugo ^{[1
]}

Haji, Keiko ^{[1
]}

Mitsuhashi, Atsushi ^{[1
]}

Morita, Yutaka ^{[1
]}

Tsukazaki, Yuki ^{[1
]}

Yabuki, Yohei ^{[1
]}

Ozaki, Ryohiko ^{[1
]}

Yoneda, Hiroto ^{[1
]}

Sato, Seidai ^{[1
]}

Hanibuchi, Masaki ^{[1
,3
]}

Bando, Yoshimi ^{[2
]}

Nokihara, Hiroshi ^{[1
,4
]}

Nishioka, Yasuhiko ^{[1
]}

机构：

[1] Tokushima Univ, Grad Sch Biomed Sci, Dept Resp Med & Rheumatol, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[2] Tokushima Univ Hosp, Div Pathol, 2-50-1 Kuramoto Cho, Tokushima 7708503, Japan

[3] Tokushima Univ, Grad Sch Biomed Sci, Dept Community Med Respirol Hematol & Metab, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[4] Ctr Hosp Natl Ctr Global Hlth & Med, Resp Med, 1-21-1 Toyama,Shinjyuku Ku, Tokyo 1628655, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2024年 / 51卷

关键词：

Small -cell lung cancer transformation; Non -small -cell lung cancer; Acquired resistance; Epidermal growth factor receptor; Tyrosine kinase inhibitors; ACQUIRED-RESISTANCE; CANCER; OSIMERTINIB; OUTCOMES; THERAPY;

D O I：

10.1016/j.rmcr.2024.102076

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Histological transformation to small -cell lung cancer (SCLC) is a well-known mechanism of acquired resistance to epidermal growth factor receptor -tyrosine kinase inhibitors (EGFR-TKIs), and almost all patients receive EGFR-TKIs at the time of transformation. We herein report three cases of EGFR -mutated lung adenocarcinoma that transformed into SCLC long after the cessation of EGFR-TKIs. Rapid tumor progression and elevated SCLC marker levels were observed at the time of transformation. Our case highlights the importance of considering SCLC transformation throughout the clinical course. Careful observation of the tumor behavior and SCLC markers should be performed to avoid diagnostic delays.

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页数：7

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