The Clinical Outcomes of Thoracoscopic Versus Open Lobectomy for Non-Small-Cell Lung Cancer After Neoadjuvant Therapy: A Multi-Center Retrospective Cohort Study

被引：2

作者：

Cao, Jinlin ^{[1
]}

Zhang, Chong ^{[1
]}

Zhang, Xun ^{[2
]}

Liu, Lunxu ^{[3
]}

Li, Xiaofei ^{[4
]}

He, Jianxing ^{[5
]}

Xu, Lin ^{[6
]}

Fu, Xiangning ^{[7
]}

Liu, Yang ^{[8
]}

Liu, Deruo ^{[9
]}

Hu, Jian ^{[1
]}

Wang, Luming ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Thorac Surg, 79 Qingchun Rd, Hangzhou, Peoples R China

[2] Tianjin Univ, Tianjin Chest Hosp, Dept Thorac Surg, Tianjin, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Thorac Surg, Chengdu, Peoples R China

[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian, Peoples R China

[5] Guangzhou Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Guangzhou, Peoples R China

[6] Nanjing Med Univ, Canc Inst Jiangsu Prov, Dept Thorac Surg, Affiliated Canc Hosp, Nanjing, Peoples R China

[7] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan, Peoples R China

[8] Chinese Peoples Liberat Army Gen Hosp, Dept Thorac Surg, Beijing, Peoples R China

[9] China Japan Friendship Hosp, Dept Thorac Surg, Beijing, Peoples R China

来源：

CLINICAL LUNG CANCER | 2024年 / 25卷 / 03期

基金：

国家重点研发计划;

关键词：

ADJUVANT CHEMOTHERAPY; SURVIVAL; IMMUNOTHERAPY;

D O I：

10.1016/j.cllc.2023.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The safety and efficacy of video-assisted thoracic surgical (VATS) versus open lobectomy for non-small-cell lung cancer (NSCLC) following neoadjuvant therapy remained controversial. This multi -center analysis of patients with NSCLC who had undergone surgery subsequent to neoadjuvant therapy reveals that VATS lobectomy tended to have a better perioperative outcome, and have a similar overall survival compared to open lobectomy. Background: The safety and efficacy of video-assisted thoracic surgical (VATS) versus open lobectomy for non-smallcell lung cancer (NSCLC) following neoadjuvant therapy remained controversial. The aim of this study was to compare the outcomes of VATS with those of open lobectomy for NSCLC after neoadjuvant therapy. Methods: Patients who had undergone VATS or open lobectomy for NSCLC following neoadjuvant therapy in nine hospitals in China from July 2014 to July 2020 were retrospectively reviewed. The clinical characteristics and overall survival (OS) of patients were analyzed using Cox regression models and propensity score matching. Results: We identified 685 patients, 436 (63.6%) who had undergone VATS lobectomy and 249 (36.4%) who had undergone open lobectomy. Patients who had undergone VATS lobectomy tended to have had fewer nodes removed than those who had undergone open lobectomy. However, compared with open group, the VATS group had a better perioperative outcome, such as smaller blood loss volumes and shorter postoperative stays. The groups had a similar operation durations and postoperative complications, and there was a nonsignificant difference between their 30-day mortality rates. After propensity score matching, there was no significant different between the OS of the groups, and only postoperative adjuvant therapy was associated with worse OS. Conclusion: This multi -center analysis of patients with NSCLC who had undergone surgery subsequent to neoadjuvant therapy reveals that VATS lobectomy tended to have a better perioperative outcome, and have a similar

引用

页码：e153 / e160

页数：8

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