Age-Stratified Seroprevalence of Respiratory Syncytial Virus: Analysis Using Prefusion F and G Protein Antibodies

被引：0

作者：

Nham, Eliel ^{[1
,2
]}

Jang, A-Yeung ^{[1
,2
]}

Hyun, Hakjun ^{[1
,2
]}

Yoon, Jin Gu ^{[1
,2
]}

Noh, Ji Yun ^{[1
,2
]}

Cheong, Hee Jin ^{[1
,2
]}

Kim, Woo Joo ^{[1
,2
]}

Ahn, Ki Bum ^{[3
]}

Ji, Hyun Jung ^{[3
]}

Seo, Ho Seong ^{[3
]}

Bae, Joon-Yong ^{[2
,4
]}

Park, Man-Seong ^{[2
,4
]}

Song, Joon Young ^{[1
,2
]}

机构：

[1] Korea Univ, Dept Internal Med, Div Infect Dis, Coll Med, Seoul 02841, South Korea

[2] Vaccine Innovat Ctr KU Med VIC K, Seoul 02841, South Korea

[3] Korea Atom Energy Res Inst, Jeongeup 56212, South Korea

[4] Korea Univ, Dept Microbiol, Coll Med, Seoul 02841, South Korea

来源：

VACCINES | 2024年 / 12卷 / 05期

关键词：

respiratory syncytial virus; RSV; seroprevalence; antibody; VACCINE; IMMUNIZATION; INFECTION; KINETICS; ADULTS; SERUM;

D O I：

10.3390/vaccines12050513

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This is a cross-sectional serosurveillance study for RSV. Between June and September of 2021, a total of 150 sera were collected from 30 individuals in each age group (<5, 5-18, 19-49, 50-64, and >= 65 years). Seroprevalence was estimated using enzyme-linked immunosorbent assays targeting two stabilized prefusion F (preF; DS-Cav1 and SC-TM) and G proteins. The overall seroprevalence was low in young children and older adults, despite them having a higher risk of severe RSV infection. There was a remarkable difference in age-stratified seroprevalence rates between anti-preF and anti-G protein antibodies. Given the high disease burden and low seroprevalence in both infants and old adults, RSV vaccination would be crucial for pregnant women and people aged over 60 years.

引用

页数：7

共 28 条

[1]

[Anonymous], NR-32832 Human Respiratory Syncytial Virus, Panel of Human Antiserum and Immune Globulin to Respiratory Syncytial Virus (Assays/Panels)

[2] A Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine With and Without Adjuvant in Healthy Older Adults [J].

Baber, James ;

Arya, Mark ;

Moodley, Yuben ;

Jaques, Anna ;

Jiang, Qin ;

Swanson, Kena A. ;

Cooper, David ;

Maddur, Mohan S. ;

Loschko, Jakob ;

Gurtman, Alejandra ;

Jansen, Kathrin U. ;

Gruber, William C. ;

Dormitzer, Philip R. ;

Schmoele-Thoma, Beate .

JOURNAL OF INFECTIOUS DISEASES, 2022, 226 (12) :2054-2063

[3]

Bennett J.E., 2014, MANDELL DOUGLAS BENN

[4] Antibody Responses to Respiratory Syncytial Virus: A Cross-Sectional Serosurveillance Study in the Dutch Population Focusing on Infants Younger Than 2 Years [J].

Berbers, Guy ;

Mollema, Liesbeth ;

van der Klis, Fiona ;

den Hartog, Gerco ;

Schepp, Rutger .

JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (02) :269-278

[5]

Bhattarakosol P, 2003, ASIAN PAC J ALLERGY, V21, P269

[6] A prospective surveillance study on the kinetics of the humoral immune response to the respiratory syncytial virus fusion protein in adults in Houston, Texas [J].

Blunck, Brittani N. ;

Aideyan, Letisha ;

Ye, Xunyan ;

Avadhanula, Vasanthi ;

Ferlic-Stark, Laura ;

Zechiedrich, Lynn ;

Gilbert, Brian E. ;

Piedra, Pedro A. .

VACCINE, 2021, 39 (08) :1248-1256

[7] The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: A systematic review [J].

Colosia, Ann D. ;

Yang, Jin ;

Hillson, Eric ;

Mauskopf, Josephine ;

Copley-Merriman, Catherine ;

Shinde, Vivek ;

Stoddard, Jeffrey .

PLOS ONE, 2017, 12 (08)

[8] Comparison of Immune Responses to Different Versions of VLP Associated Stabilized RSV Pre-Fusion F Protein [J].

Cullen, Lori M. ;

Schmidt, Madelyn R. ;

Torres, Gretel M. ;

Capoferri, Adam A. ;

Morrison, Trudy G. .

VACCINES, 2019, 7 (01)

[9] Respiratory syncytial virus infection in adults [J].

Falsey, AR ;

Walsh, EE .

CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (03) :371-+

[10] A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism [J].

Krarup, Anders ;

Truan, Daphne ;

Furmanova-Hollenstein, Polina ;

Bogaert, Lies ;

Bouchier, Pascale ;

Bisschop, Ilona J. M. ;

Widjojoatmodjo, Myra N. ;

Zahn, Roland ;

Schuitemaker, Hanneke ;

McLellan, Jason S. ;

Langedijk, Johannes P. M. .

NATURE COMMUNICATIONS, 2015, 6

← 1 2 3 →