Predictors of long-term survival after resection of adenocarcinoma arising from intraductal papillary mucinous neoplasm and derivation of a prognostic model: An international multicenter study (ADENO-IPMN study)

被引：1

作者：

Lucocq, James ^{[1
]}

Joseph, Nejo ^{[2
]}

Hawkyard, Jake ^{[2
]}

Haugk, Beate ^{[2
]}

White, Steve ^{[2
]}

Lye, Jonathan ^{[2
]}

Parkinson, Daniel ^{[2
]}

Mownah, Omar ^{[3
]}

Menon, Krishna ^{[3
]}

Furukawa, Takaki ^{[4
]}

Hirose, Yuki ^{[4
]}

Sasahira, Naoki ^{[4
]}

Inoue, Yosuke ^{[4
]}

Mittal, Anubhav ^{[5
]}

Samra, Jas ^{[5
]}

Sheen, Amy ^{[6
]}

Feretis, Michael ^{[7
]}

Balakrishnan, Anita ^{[7
]}

Ceresa, Carlo ^{[8
]}

Davidson, Brian ^{[8
]}

Pande, Rupaly ^{[9
]}

Dasari, Bobby ^{[9
]}

Roberts, Keith ^{[9
]}

Tanno, Lulu ^{[10
]}

Karavias, Dimitrios ^{[10
]}

Helliwell, Jack ^{[11
]}

Young, Alistair ^{[11
]}

Marks, Kate ^{[11
]}

Nunes, Quentin ^{[12
]}

Urbonas, Tomas ^{[13
]}

Silva, Michael ^{[13
]}

Gordon-Weeks, Alex ^{[13
]}

Barrie, Jenifer ^{[14
]}

Gomez, Dhanny ^{[14
]}

van Laarhoven, Stijn ^{[15
]}

Nawara, Hossam ^{[15
]}

Doyle, Joseph ^{[16
]}

Bhogal, Ricky ^{[16
]}

Harrison, Ewen ^{[17
]}

Roalso, Marcus ^{[18
]}

Ciprani, Debora ^{[19
]}

Aroori, Somaiah ^{[19
]}

Ratnayake, Bathiya ^{[20
]}

Koea, Jonathan ^{[20
]}

Capurso, Gabriele ^{[21
,22
]}

Stattner, Stefan ^{[23
]}

Bellotti, Ruben ^{[24
]}

Alsaoudi, Tareq ^{[24
]}

Bhardwaj, Neil ^{[24
]}

Rajesh, Srujan ^{[24
]}

机构：

[1] NHS Lothian, Dept Gen Surg, Aberdeen, Scotland

[2] Freeman Rd Hosp, Hepatopancreatobiliary & Transplant Unit, Newcastle Upon Tyne, England

[3] Kings Coll Hosp London, Dept Hepatobiliary & Pancreat Surg, Denmark Hill, London, England

[4] Canc Inst Hosp Japanese Fdn Canc Res, Hepatobiliary Pancreat Med Dept, Tokyo, Japan

[5] Royal North Shore Hosp, Sydney, NSW, Australia

[6] Royal North Shore Hosp, Dept Anat Pathol, New South Wales Hlth Pathol, Sydney, NSW, Australia

[7] Addenbrookes Hosp, Cambridge Hepatobiliary & Pancreat Surg Unit, Cambridge, England

[8] Royal Free Hosp, Hepatobiliary & Pancreat Surg Unit, London, England

[9] Queen Elizabeth Hosp Birmingham, Univ Hosp Birmingham NHS Fdn Trust, Hepatobiliary & Pancreat Surg Unit, Birmingham, England

[10] Univ Hosp Southampton, Hepatobiliary & Pancreat Surg Unit, Acad Surg Unit, Southampton, England

[11] Leeds Teaching Hosp NHS Fdn Trust, Hepatobiliary & Pancreat Surg Unit, Leeds, England

[12] East Lancashire Teaching Hosp NHS Trust, Dept Hepatobiliary Surg, Blackburn, Lancs, England

[13] Oxford Univ Hosp NHS Fdn Trust, Oxford Hepatopancreatobiliary HPB Surg Unit, Oxford, England

[14] Nottingham Univ Hosp NHS Fdn Trust, Nottingham Hepatopancreaticoniliary HPB Serv, Nottingham, England

[15] Univ Hosp Bristol & Weston NHS Fdn trust, Dept Hepatobiliary & Pancreat Surg, Bristol, England

[16] Royal Marsden NHS Fdn Trust, Gastrointestinal Unit, London, England

[17] Univ Edinburgh, Dept Clin Surg, Edinburgh, Scotland

[18] Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway

[19] Univ Hosp Plymouth NHS Trust, Hepatopancreatobiliary Unit, Plymouth, England

[20] North Shore Hosp, Hepatopancreaticobiliary Upper Gastrointestinal Un, Auckland, New Zealand

[21] S Andrea Hosp, Digest & Dis Unit, Rome, Italy

[22] Univ Vita Salute San Raffaele, San Raffaele Sci Inst IRCCS, Pancreas Ctr, Milan, Italy

[23] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria

[24] Univ Hosp Leicester NHS Trust, Leicester Hepatopancreatobiliary Unit, Leicester, England

[25] Christchurch Hosp, Dept Gen & Vasc Surg, Canterbury Dist Hlth Board, Canterbury, New Zealand

[26] Univ Glasgow, Res Inst Canc Sci, Wolfson Wohl Canc Res Ctr, Glasgow, Scotland

[27] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia

来源：

SURGERY | 2024年 / 176卷 / 03期

关键词：

PANCREATIC-CANCER; ADJUVANT THERAPY; MANAGEMENT; DISTINCT; IMPACT;

D O I：

10.1016/j.surg.2024.05.010

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Predictors of long-term survival after resection of adenocarcinoma arising from intraductal papillary mucinous neoplasms are unknown. This study determines predictors of long-term (>5 years) disease-free survival and recurrence in adenocarcinoma arising from intraductal papillary mucinous neoplasms and derives a prognostic model for disease-free survival. Methods: Consecutive patients who underwent pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasms in 18 academic pancreatic centers in Europe and Asia between 2010 to 2017 with at least 5-year follow-up were identified. Factors associated with disease-free survival were determined using Cox proportional hazards model. Internal validation was performed, and discrimination and calibration indices were assessed. Results: In the study, 288 patients (median age, 70 years; 52% male) were identified; 140 (48%) patients developed recurrence after a median follow-up of 98 months (interquartile range, 78.4-123), 57 patients (19.8%) developed locoregional recurrence, and 109 patients (37.8%) systemic recurrence. At 5 years after resection, the overall and disease-free survival was 46.5% (134/288) and 35.0% (101/288), respectively. On Cox proportional hazards model analysis, multivisceral resection (hazard ratio, 2.20; 95% confidence interval, 1.06-4.60), pancreatic tail location (hazard ratio, 2.34; 95% confidence interval, 1.22-4.50), poor tumor differentiation (hazard ratio, 2.48; 95% confidence interval, 1.10-5.30), lymphovascular invasion (hazard ratio, 1.74; 95% confidence interval, 1.06-2.88), and perineural invasion (hazard ratio, 1.83; 95% confidence interval, 1.09-3.10) were negatively associated with long-term disease-free survival. The final predictive model incorporated 8 predictors and demonstrated good predictive ability for disease-free survival (C-index, 0.74; calibration, slope 1.00). Conclusion: A third of patients achieve long-term disease-free survival (>5 years) after pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasms. The predictive model developed in the current study can be used to estimate the probability of long-term disease-free survival. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：890 / 898

页数：9

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