T-bet+ B Cells in Humans: Protective and Pathologic Functions

The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation have identified a novel human B-cell subset that expresses the transcription factor T-bet and exerts pleiotropic functions by disease state. Here, we review the generation, activation, and functions of the T-bet(+) B-cell subset outside of allotransplantation, and consider the relevance of this subset as mediators of allograft injury.