T-bet+ B Cells in Humans: Protective and Pathologic Functions

被引：2
作者：
Nellore, Anoma [1 ]
Zumaquero, Esther [2 ]
Seifert, Michael [3 ]
机构：
[1] Univ Alabama Birmingham, Div Infect Dis, Birmingham, AL USA
[2] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL USA
[3] Univ Alabama Birmingham, Div Pediat Nephrol, Birmingham, AL USA
来源：
TRANSPLANTATION | 2024年 / 108卷 / 08期
关键词：
T-BET; TRANSCRIPTION FACTOR; ALLOGRAFT INFLAMMATION; PROTOCOL BIOPSIES; POPULATION; INFECTION; RESPONSES; ANTIBODY; SUBSETS; CONTAIN;
D O I：
10.1097/TP.0000000000004889
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation have identified a novel human B-cell subset that expresses the transcription factor T-bet and exerts pleiotropic functions by disease state. Here, we review the generation, activation, and functions of the T-bet(+) B-cell subset outside of allotransplantation, and consider the relevance of this subset as mediators of allograft injury.
引用
收藏
页码：1709 / 1714
页数：6
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