Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation

被引:2
作者
Liu, Pan [1 ,2 ]
Wang, Lili [1 ]
Yu, Huiying [1 ]
机构
[1] Gen Hosp Northern Theater Command, Lab Basic Med, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Beifang Hosp, Shenyang, Liaoning, Peoples R China
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2024年 / 12卷
基金
英国科研创新办公室;
关键词
polyploid giant cancer cells; giant cell cycle; epithelial-mesenchymal transition; apoptosis; autophagy; senescence; TUMOR-CELLS; GENOMIC INSTABILITY; CELLULAR SENESCENCE; MITOTIC CATASTROPHE; DOWN-REGULATION; OVARIAN-CANCER; EXPRESSION; ACTIVATION; CISPLATIN; APOPTOSIS;
D O I
10.3389/fcell.2024.1410637
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Polyploid giant cancer cells (PGCCs) are characterized by the presence of either a single enlarged nucleus or multiple nuclei and are closely associated with tumor progression and treatment resistance. These cells contribute significantly to cellular heterogeneity and can arise from various stressors, including radiation, chemotherapy, hypoxia, and environmental factors. The formation of PGCCs can occur through mechanisms such as endoreplication, cell fusion, cytokinesis failure, mitotic slippage, or cell cannibalism. Notably, PGCCs exhibit traits similar to cancer stem cells (CSCs) and generate highly invasive progeny through asymmetric division. The presence of PGCCs and their progeny is pivotal in conferring resistance to chemotherapy and radiation, as well as facilitating tumor recurrence and metastasis. This review provides a comprehensive analysis of the origins, potential formation mechanisms, stressors, unique characteristics, and regulatory pathways of PGCCs, alongside therapeutic strategies targeting these cells. The objective is to enhance the understanding of PGCC initiation and progression, offering novel insights into tumor biology.
引用
收藏
页数:15
相关论文
共 167 条
  • [1] p21 in cancer: intricate networks and multiple activities
    Abbas, Tarek
    Dutta, Anindya
    [J]. NATURE REVIEWS CANCER, 2009, 9 (06) : 400 - 414
  • [2] Zoledronic acid targets chemo-resistant polyploid giant cancer cells
    Adibi, Rezvan
    Moein, Shiva
    Gheisari, Yousof
    [J]. SCIENTIFIC REPORTS, 2023, 13 (01):
  • [3] From Sprouting Angiogenesis to Erythrocytes Generation by Cancer Stem Cells: Evolving Concepts in Tumor Microcirculation
    Alameddine, Raafat S.
    Hamieh, Lana
    Shamseddine, Ali
    [J]. BIOMED RESEARCH INTERNATIONAL, 2014, 2014
  • [4] ALBITAR M, 1992, BLOOD, V79, P2471
  • [5] Alfarouk Khalid O, 2011, Cancers (Basel), V3, P3002, DOI 10.3390/cancers3033002
  • [6] Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN Status
    Alhaddad, Lina
    Chuprov-Netochin, Roman
    Pustovalova, Margarita
    Osipov, Andreyan N.
    Leonov, Sergey
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (02)
  • [7] Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance
    Amend, Sarah R.
    Torga, Gonzalo
    Lin, Ke-Chih
    Kostecka, Laurie G.
    de Marzo, Angelo
    Austin, Robert H.
    Pienta, Kenneth J.
    [J]. PROSTATE, 2019, 79 (13) : 1489 - 1497
  • [8] Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution
    Bakhoum, Samuel F.
    Landau, Dan Avi
    [J]. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2017, 7 (06):
  • [9] The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
    Bao, Bin
    Azmi, Asfar S.
    Ali, Shadan
    Ahmad, Aamir
    Li, Yiwei
    Banerjee, Sanjeev
    Kong, Dejuan
    Sarkar, Fazlul H.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02): : 272 - 296
  • [10] Baskar Rajamanickam, 2014, Front Mol Biosci, V1, P24, DOI 10.3389/fmolb.2014.00024